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Iranian Journal of Nuclear Medicine، جلد ۱۶، شماره ۲، صفحات ۳۴-۴۰
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عنوان انگلیسی Evaluation of radiolabeled streptokinase for thrombosis imaging
چکیده انگلیسی مقاله Introduction: Cardiovascular disease is the major cause of morbidity and mortality in developing and developed countries. Rapid diagnosis of the thrombosis can be an essential step in management of the stroke. Methods: In this work a recently developed radiolabeled streptokinase (STP) tracer was evaluated in an animal thrombotic model using SPECT imaging and biodistribution studies. Locally labeled [67Ga]-Streptokinase was checked by ITLC, HPLC and SDS-PAGE experiments to check the tracer integrity and purity. The biodistribution studies were performed in thrombotic femoral vein of rats using tissue counting and preliminary SPECT studies, respectively (up to 2 h). Results: [67Ga]-Streptokinase prepared with suitable radiochemical purity (HPLC >95%, ITLC >99%) was administered to FeCl3 induced thrombotic rats and the percentage of injected dose per gram of tissue (ID/g%) as well as the SPECT images demonstrated the good specific binding of the tracer in thrombotic clots located in heart and aorta 2 hours post injection. Conclusion: [67Ga]-DTPA-STP can be a suitable probe for imaging of thrombosis in cardiovascular diseases. Ga-68 labeled STP has the potential to be an alternative superior labeled compound due to positron emission properties for PET studies as well as appropriate physical half life.
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نویسندگان مقاله امیررضا جلیلیان | amir reza
agricultural, medical and industrial research school, nstri, karaj, iran

فاطمه میرعزیزی |
biochemistry department, payam-e-noor university, district 10, tehran, iran

حبیب اله ناظم |
biochemistry department, payam-e-noor university, district 10, tehran, iran

kammaledin شفایی |
agricultural, medical and industrial research school, nstri, karaj, iran

بهنام nasserian |
agricultural, medical and industrial research school, nstri, karaj, iran

حسین صادق پور |
faculty of pharmacy, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_514_22b133418a251a1211b2f32ba4a0b228.pdf
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