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Iranian Journal of Nuclear Medicine، جلد ۱۶، شماره ۱، صفحات ۲۰-۲۴
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عنوان انگلیسی Synthesis, labeling and quality control of a new Neuropeptide Y analogue for diagnosis of breast tumors
چکیده انگلیسی مقاله Introduction: Over expression of selected peptide receptors in human tumors has been shown to represent clinically relevant targets for cancer diagnosis and therapy. The aim of this work was to investigate Neuropeptide Y (NPY) as a new radiopharmaceutical for diagnosis of breast cancer. Methods: A neuropeptide Y analogues with Y1 receptor preference and agonistic properties was synthesized by solid phase method. After conjugation with diethylenetriaminepentaacetic acid (DTPA) labeling with 111In was performed. For labeled peptide, yield of labeling, stability in human serum, receptor binding in cell surface with internalization in SK-N-MC cells, and biodistribution in normal rat were determined. Results: Peptide was synthesized and labeled with more than 95% purity. Radiolabeled peptide was stable in human serum and specifically binds and internalized in the cells with Y1 receptor (4h = 22%). A rapid clearance from blood pool and urinary with hepatobiliary excretion were observed. Conclusion: Our results showed that this peptide can be considered as a candidate for diagnosis of breast tumors
کلیدواژه‌های انگلیسی مقاله Neuropeptide Y,DTPA,In-111,Tumor
نویسندگان مقاله مصطفی گندمکار |
nuclear science research school, nuclear science amp;amp; technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

رضا نجفی |
nuclear science research school, nuclear science amp;amp; technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد مزیدی |
nuclear science research school, nuclear science amp;amp; technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

مصطفی گودرزی |
nuclear science research school, nuclear science amp;amp; technology research institute nstri , atomic energy organization of iran, tehran, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

سید اسماعیل سادات ابراهیمی | seyed esmaeil sadat ebrahimi
department of medicinal chemistry, faculty of pharmacy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_503_bee82312635664ab9a5047cfc4f7296e.pdf
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