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Iranian Journal of Nuclear Medicine، جلد ۱۴، شماره ۲، صفحات ۳۵-۴۱
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عنوان انگلیسی Experimental production and initial imaging of [18F]-14-Fluoro-6-thia-heptadecanoic acid ([18F]-FTHA) for myocardial performance [Persian]
چکیده انگلیسی مقاله Introduction: [18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. Methods: [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier-added (n.c.a) form from Benzyl-14-tosyloxy-6-thia-heptadecanoate 1 in one step at 90C in Kryptofix2.2.2/[18F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester 2 was then hydrolyzed to yield [18F]-6-thia-14-fluoro-heptadecanoic 3b. The final solution was concentrated using C18 SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies. Results: The synthesis took 15 min with overall radiochemical yield of 15-25% (EOS) and chemical-radiochemical purity more than 94%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be 140-180 minutes post injection. Conclusions: Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [18F]-FTHA can be obtained without HPLC purification step.
کلیدواژه‌های انگلیسی مقاله PET imaging,Radiochemical,Fluorine-18,Myocardium
نویسندگان مقاله امیررضا جلیلیان | amir reza
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

مهدی اخلاقی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

فریبا سدادی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد میرزایی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

علیرضا کریمیان |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

مهربان پولادی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

یوسف یاری کامرانی | yari kamrani
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

صدیقه مرادخانی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

نامی shadanpour |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

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