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Iranian Journal of Nuclear Medicine، جلد ۱۳، شماره ۱، صفحات ۱۹-۲۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]
چکیده انگلیسی مقاله In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final sample was injected into fibrosarcoma-bearing mice via their tail vein. Satisfactory preliminary SPECT images were acquired between 2-4 hours post-injection showing suitable accumulation in fibrosarcoma tumors.
کلیدواژه‌های انگلیسی مقاله Radiopharmaceutical,In-111,Bleomycin,Fibrosarcoma
نویسندگان مقاله امیررضا جلیلیان | amir reza
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد میرزایی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

علیرضا کریمیان |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

جمشید معافیان |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

غلامرضا اصلانی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

صدیقه مرادخانی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محسن کمالی دهقان | kamali dehghan
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

سعید دانشوری |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

فرج تابعی |
shaheed beheshti university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

غلامرضا رییس علی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

نشانی اینترنتی http://irjnm.tums.ac.ir/article_455_5db9df639b806ea9ac15165842b23de8.pdf
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