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Iranian Journal of Nuclear Medicine، جلد ۱۳، شماره ۱، صفحات ۳۸-۵۰
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Production, formulation and quality control of [13N]NH3 compound for PET imaging of regional blood flow [Persian]
چکیده انگلیسی مقاله In this study, 16O(p,α)13N nuclear reaction was chosen as the best method of N-13 production. High purity natural water targets were bombarded by 18 MeV protons with an intensity of 8μA. A production yield of 13.5 mCi/μAh was obtained. Chemical modification of 13N-nitrogen oxides into [13N]NH3 was accomplished using De Varda's catalyst. Chemical, radiochemical and radionuclide purity controls performed on the final product showed high radiopharmaceutical purity (>98%) in the form of [13N]NH3. [13N]NH3 was formulated in normal saline media at appropriate pH and sterile conditions. Microbial and LAL tests were performed on the final product in order to assure its safety for administration to experimental subjects.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله امیررضا جلیلیان | amir reza
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

پژمان rowshanfarzad |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

آرمیتا ضیایی |
physics department, science and research center of islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

مهشید ثابت |
ssdl and health physics department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

محمد میرزایی |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

داریوش سرداری |
physics department, science and research center of islamic azad university, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

جمشید معافیان |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

علی ستاری |
cyclotron and nuclear medicine department, agricultural, medical and industrial research school, nuclear science and technology research institute, atomic energy organization of iran, karaj, iran
سازمان اصلی تایید شده: سازمان انرژی اتمی (Atomic energy organization)

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