این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Nuclear Medicine، جلد ۱۲، شماره ۱، صفحات ۳۳-۳۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Synthesis, formulation and quality control of 99mTc-HYNIC-hlgG for imaging focal sites of infection and inflammation in human subjects [Persian]
چکیده انگلیسی مقاله Imaging of infection and inflammation is an important issue in nuclear medicine as it may have relevant implication for the management of patients with infections or inflammatory diseases. In this regard the synthesis of human polyclonal immunoglobuline G (IgG) radiolabeled with technetium-99m (99mTc) by a novel method, via a nicotinamide hydrazine derivative, was performed. The biological behavior, stability and its high specific activity make this radiopharmaceutical a suitable reagent for radiolabeling of proteins and peptides. In this article the method for synthesis of a sterile and apyrogen 99mTc-HYNIC-hIgG kit is presented. The preparation of the kit consists two steps, in the first step 740 MBq pertechnetate was added in Kit No.1, which contains SnCl2 and tricine. After 5 minutes the aliquot in Kit No.1 was added to Kit No.2, which contains HYNIC-hIgG. 99mTc-HYNIC-hIgG complex is stable in cysteine and serum with a labeling efficiency more than 90% after one hour.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمد حسین بابایی | mohammad hossein
department of radioisotope, nuclear research center, aoei, tehran, iran

محمد شفیعی |
department of radioisotope, nuclear research center, aoei, tehran, iran

پیام بهرادکیا |
department of radioisotope, nuclear research center, aoei, tehran, iran

رضا نجفی |
department of radioisotope, nuclear research center, aoei, tehran, iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_437_06c5db325e16e1e19089af129e9dd9eb.pdf
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات