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International Journal of Pediatrics، جلد ۵، شماره ۳، صفحات ۴۵۶۹-۴۵۷۴
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عنوان انگلیسی Study of Polymorphism of the DRD2 Gene (-141C Ins/Del, rs1799732) with Attention Deficit Hyperactivity Disorder a Population Sample of Children in Iranian-Azeri
چکیده انگلیسی مقاله BackgroundAttention deficit hyperactivity disorder (ADHD), is a multifactorial disorder and converging evidence has implicated abnormalities of dopamine neurotransmission. The aim of this study was to examine the association of -141 polymorphisms in DRD2 gene with ADHA among Iranian-Azeri population.Materials and Methods A case–control association study included 153 patients with attention deficit hyper activity disorder (case group), and 133 healthy subjects (control group). Genomic DNA was extracted peripheral blood samples by salting-out method. Single nucleotide polymorphism (SNP) genotyping was performed by Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. The data analysis was performed through Chi-square, with a significance level of 0.05.Results: There was not significant difference in the allele and genotype frequencies between ADHD and -141C Ins/Del polymorphism in cases and controls (P>0.05). Ins/Ins homozygous dominants were more frequent in control group than the case group, but there was not significant difference observed (P>0.05). Del/Del homozygous dominants were not observed. No significant difference was detected in the allele and genotype frequencies between ADHD and -141 Insertion/Deletion polymorphism in cases and control groups (P>0.05).ConclusionOur results do not detected association between the -141C Ins/Del, rs1799732, polymorphism and ADHD disorder in population of Children in Iranian-Azeri.
کلیدواژه‌های انگلیسی مقاله ADHD, DRD2 gene, Iranian children, Polymorphism
نویسندگان مقاله لیلا مهدیزاده فایند | leila mehdizadeh fanid
cognitive neuroscience, phd. department of biology faculty of natural sciences. university of tabriz, 29 bahman bolvard, tabriz, iran, ir.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

مینا آدمپورزارع | mina adampourezare
physiology, msc. department of biology faculty of natural sciences. university of tabriz, 29 bahman bolvard, tabriz, iran, ir.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

محمد علی حسینپورفیضی | mohammad ali hosseinpourfeizi
radiobiology, prof. department of biology faculty of natural sciences. university of tabriz, 29 bahman bolvard, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

سیدغلامرضا نورآذر | seyedgholamreza noorazar
child and adolescent psychiatrist md amp;amp; psychiatry assistant professor of tabriz university of medical science, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

نشانی اینترنتی http://ijp.mums.ac.ir/article_8107.html
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