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Medical Journal of Islamic Republic of Iran، جلد ۳۰، شماره ۱، صفحات ۱۱۰۹-۱۱۱۹
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عنوان انگلیسی Acellular pertussis vaccine efficacy: An updated systematic review and meta –analysis
چکیده انگلیسی مقاله Background: Recent studies indicate an increased incidence of pertussis disease in recent years. The aim of this study was to evaluate the efficacy of the acellular vaccine for children (as a replacement of current whole cell vaccine in the Expanded Program on Immunization) and for high-risk adults in Iran through updating current best available evidence. Methods: We performed a systematic literature review in relevant databases we focused on previously published systematic reviews to select those that address our questions. The AMSTAR (assessing the methodological quality of systematic reviews) tool was used for screening available reviews. Then search in databases was done until Feb 2014 to update the evidence. We pooled results using meta-analysis methods by Stata statistical package. Results: Eleven systematic review articles were included in the initial evaluation. In the end, two systematic reviews on acellular vaccine booster doses and the acellular vaccine in children were selected as the baseline evidence. In the update phase, new clinical trials were screened, and the results were updated. Overall pooled estimate of relative efficacy of acellular to whole cell was 0.68 (95% CI, 0.55–0.81) for children immunization Pooled estimates for the efficacy of acellular versus placebo were 0.70 (95% CI, 0.60–0.80). Overall pooled estimate of efficacy of booster dose of acellular was 0.87(95% CI, 0.85–0.88) compared to placebo. In addition pooled estimate of acellular vaccine efficacy based on response to antigen was 0.78(95% CI, 0.64–0.93) in high-risk group. Conclusion: The results show higher performance and safety of the acellular vaccine in the prevention of pertussis in children versus the whole cell vaccine. Moreover, the efficacy of the acellular vaccine in high-risk adult groups is acceptable. This study provides evidence in favor of the introduction of an acellular vaccine to the national program of immunization. Studies on cost effectiveness and aspects of policy analysis are recommended.
کلیدواژه‌های انگلیسی مقاله Whooping cough, Acellular vaccine, Whole cell vaccine.
نویسندگان مقاله رکسانا منصور قناعی | roxana mansour ghanaei
pediatric infections research center, mofid children hospital, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مازیار مرادی لاکه | maziar moradi lakeh
preventive medicine and public health research center, department of community medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

ساره شاکریان | sareh shakerian
school of medical education, shahid beheshti university of medical sciences and health services, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

عبدالله کریمی | abdollah karimi
pediatric infections research center, mofid children hospital, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

شوکا اسماعیلی | shooka esmaeeli
tehran university of medical sciences, iranian research center for hiv aids ircha , iranian institute for reduction of high-risk behaviors, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرهاد شکرانه | farhad shokraneh
cochrane schizophrenia group, the institute of mental health, a partnership between the university of nottingham and notting-hamshire healthcare nhs trust, uk.


سوسن محمودی | susan mahmoudi
center for communicable disease control, ministry of health and medical education, tehran, iran.

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

محسن یعقوبی | mohsen yaghoubi
clinical knowledge management unit, department of community medicine, iran university of medical science, tehran, iran.
نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-1084&slc_lang=en&sid=en
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زبان مقاله منتشر شده en
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