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Physiology and Pharmacology، جلد ۲۱، شماره ۱، صفحات ۴۴-۵۳
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Olive leaf extract reverses the behavioral disruption and oxidative stress induced by intrastriatal injection of 6-hydroxydopamine in rats
چکیده انگلیسی مقاله Introduction: Oxidative stress seems to play a critical role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD). Antioxidant compounds can deactivate and scavenge free radical. Olive leaves are considered as a useful source of phenolic compounds. Therefore, this study was designed to investigate the effects of methanolic olive leaf extract (OLE) on neurobehavioral activity and antioxidant enzyme activity, malondialdehyde (MDA) and glutathione (GSH) levels in striatum of rats in an experimental model of PD. Methods: The PD was induced in animals by intrastriatal injection of 6-hydroxydopamin unilaterally. Animals were pretreated with the OLE (50, 100 and 150 mg/kg body weight) for 7 weeks, and then behavioral activity (narrow beam and grip testes) and antioxidant parameters were evaluated. Results: In our study behavioral testes showed improvement in motor coordination and balance behavior in rats pretreated with OLE. Furthermore the extract of olive leaf restored the activity of antioxidant enzymes (superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase) and decreased MDA and increased GSH levels in the brain of rats. Conclusion: Our results suggest that OLE shows a neuroprotective effect in animal models of Parkinson's disease.
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نویسندگان مقاله محبوبه آقاگل زاده | mahboobeh aghagolzadeh
department of biology, faculty of basic sciences, university of mazandaran, babolsar, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

اکبر حاجی زاده مقدم | akbar hajizadeh moghaddam
department of biology, faculty of basic sciences, university of mazandaran, babolsar, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

باقر سید علیپور | bagher seyedalipour
department of cellular and molecular biology, faculty of basic sciences, university of mazandaran, babolsar, iran

سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)

نشانی اینترنتی http://phypha.ir/ppj/browse.php?a_code=A-10-625-3&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/26/article-26-327726.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurodegeneretive diseases
نوع مقاله منتشر شده Original Research
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