این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Medical Journal of Islamic Republic of Iran، جلد ۲۸، شماره ۱، صفحات ۷۹۳-۸۰۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of adenosine A2a receptor agonist and antagonist on cere-bellar nuclear factor-kBexpression preceded by MDMA toxicity
چکیده انگلیسی مقاله Background :Adenosine is an endogenous purine nucleoside that has a neuromodulatory role in the central nervous system. The amphetamine derivative (±)-3,4-methylenedioxymethamphetamine (MDMA or ecstasy) is a synthetic amphetamine analogue used recreationally to obtain an enhanced affiliated emotional response. MDMA is a potent monoaminergic neurotoxin with the potential of damage to brain neurons. The NF-kBfamilyof proteins are ubiquitously expressed and are inducible transcription factors that regulate the expression of genes involved in disparate processes such as immunity and ingrowth, development and cell-death regulation. In this study we investigated the effects of the A2a adenosine receptor (A2a-R) agonist (CGS) and antagonist (SCH) on NF-kB expression after MDMA administration. Methods : Sixty three male Sprague–Dawley rats were injected to MDMA (10 and 20mg/kg) followed by intraperitoneal CGS (0.03 mg/kg) or SCH (0.03mg/kg) injection. The cerebellum were then removed forcresyl-violet staining, western blot and RT- PCR analyses. MDMA significantly elevated NF-kB expression. Our results showed that MDMA increased the number of cerebellar dark neurons. Results : We observed that administration of CGS following MDMA, significantly elevated the NF-kB expression both at mRNA and protein levels. By contrast, administration of the A2a-R antagonist SCH resulted in a decrease in the NF-kB levels. Conclusion : These results indicated that, co-administration of A2a agonist (CGS) can protect against MDMA neurotoxic effects by increasing NF-kB expression levels suggesting a potential application for protection against the neurotoxic effects observed in MDMA users.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله فاطمه کرمانیان | fatemeh kermanian
department of anatomy, school of medicine, alborz university of medical sciences, karaj, iran.


منصوره سلیمانی | mansoureh soleimani
cellular and molecular research center, department of anatomy, iran university of medical sciences iums , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Cellular and Molecular Research Center

باقر پورحیدر | bagher pourheydar
neurophysiology research center, department of anatomy, urmia university of medical sciences, urmia, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
سازمان های دیگر: Neurophysiology Research Center

علیرضا سام زاده کرمانی | alireza samzadeh kermani
chemistry department, faculty of sciences, zabol university, zabol, iran.

سازمان اصلی تایید شده: دانشگاه زابل (Zabol university)

فرزانه محمدزاده | farzaneh mohammadzadeh
department of anatomy,iran university of medical sciences ,tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مهدی مهدی زاده | mehdi mehdizadeh
cellular and molecular research center, faculty of advanced technology in medicine, department ofanatomy, iran university of medical sciences iums , tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
سازمان های دیگر: Cellular and Molecular Research Center

نشانی اینترنتی http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1569-2&slc_lang=en&sid=en
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده 1
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات