این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Research in Pharmaceutical Sciences، جلد ۱۹، شماره ۵، صفحات ۵۰۹-۵۱۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Curcumin and exercise prevent depression via alleviating hippocampus injury and improve depressive-like behaviors in chronically stressed depression rats
چکیده انگلیسی مقاله Background and purpose: Depression is a growing public health concern worldwide, characterized by cognitive impairment and structural abnormalities of the hippocampus. Current antidepressant treatment sometimes causes the late onset of results and the much faster occurrence of side effects. For this reason, the interest in new treatment strategies including exercise and natural products such as curcumin has increased to treat depression. The present study investigated the role of curcumin and exercise in improving depressive-like behavior and hippocampal damage induced by mild unpredictable chronic stress in male rats. Experimental approach: This study analyzed the effects of curcumin (100 mg/kg/day, P.O for 14 days) and exercise (treadmill running, 45 min/day for 14 days) on immobility behavior (forced swimming test), locomotor activity (open field test), anhedonia (sucrose preference test) and cell survival (Nissl staining) of the hippocampal CA3 region in chronically stressed depression rats. Findings/Results: In the current study, curcumin treatment combined with exercise effectively improved immobility behavior, locomotor activity, and increased hippocampal cell survival resulted in preventing the development of hippocampus dysfunction and depressive-like behaviors. Conclusion and implications: This study demonstrated a new prospect for treating depression. The current findings give researchers the confidence to continue the investigations on the effects of curcumin accompanied with exercise as a novel therapy for the treatment of depression.    
کلیدواژه‌های انگلیسی مقاله Chronic stress,Curcumin,Depressive behaviors,Exercise,Hippocampus injury.
نویسندگان مقاله | Elaheh Ahmadi
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Ali Pourmotabbed
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Nilofar Aghaz
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Seyed Ershad Nedaei
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Mojgan Veisi
Department of Biology, Faculty of Science, University of Qom, Qom, I.R. Iran.


| Zahra Salimi
Department of Biology, Faculty of Science, Razi University, Kermanshah, I.R. Iran.


| Fatemeh Zarei
Department of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Cyrus Jalili
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Farshad Moradpour
Department of Physiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.


| Motahareh Zeinivand


نشانی اینترنتی http://rps.mui.ac.ir/index.php/jrps/article/view/2270
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات