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International Journal of Radiation Research، جلد ۲۲، شماره ۴، صفحات ۸۱۷-۸۲۲
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عنوان انگلیسی Radiation dose estimation of human organs for 177Lu-anti-EGFR-PAMAM complex
چکیده انگلیسی مقاله
Background: Nowadays, radiolabeled monoclonal antibodies (mAbs) are satisfactorily used for the diagnosis and therapy of different types of cancers. In this study, the human absorbed dose of 177Lu-Cetuximab-PAMAM was estimated based on the biodistribution data in tumor-bearing mice. Materials and Methods: 177Lu-DTPA-CHX-Cetuximab-PAMAM was prepared after the conjugation of cetuximab to PAMAM nanoparticles and DTPA-CHX to mAb-PAMAM. The biodistribution of the labeled nano-system was studied in the tumor-bearing nude mice up to 72 h after injection. The absorbed dose of human organs was calculated according to the animals’ data utilizing the radiation absorbed dose assessment resource (RADAR) and the relative mass extrapolation methods. Results: The radiolabeled compound, prepared at the optimized conditions, had a radiochemical purity (RCP) of 99.6% ± 0.4% (P < 0.05).  Most of the activity was accumulated in the tumor site (10.14 ± 0.89; P < 0.05). The liver and the kidneys received the highest absorbed dose with 0.561 and 0.207 mSv/MBq, respectively, which is lesser than the other monoclonal antibodies labeled with 177Lu. Conclusion: Considering the special characteristics of 177Lu-DTPA-CHX-Cetuximab-PAMAM, this radiolabeled nano-system can be considered as a safe and effective radiolabeled compound for treatment of EGFR-expressing tumors.
کلیدواژه‌های انگلیسی مقاله PAMAM, Radiation, Dose, Lutetium-177, anti-EGFR.
نویسندگان مقاله | S. Zolghadri
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, 14155-1339, Iran


| M. Rabiei
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, 14155-1339, Iran


| A. Karimian
Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, 14155-1339, Iran


| S.M. Hosseini
Department of Life Science Engineering, Faculty of Modern Science and Technology, Nano Biotechnology Group, University of Tehran, Tehran, 1439957131, Iran
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1244&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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