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Iranian Journal of Nuclear Medicine، جلد ۳۳، شماره ۱، صفحات ۴-۱۱
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عنوان انگلیسی Second primary cancer prevalence in differentiated thyroid cancer patients and correlation with thyroid primary tumor stage: A population-based cohort study in Iran
چکیده انگلیسی مقاله Introduction: Thyroid cancer is the most common endocrine malignancy. This often involves the middle-aged and active population, typically younger compared to those with other types of cancers. Some people with thyroid cancer may develop secondary malignancy. The reason for this is not well understood. This study was designed to evaluate the prevalence of second primary cancers in patients with differentiated thyroid cancer and its probable relationship with the severity of treatment and staging of the primary tumor.
Methods: Among 2638 patients who underwent thyroidectomy between 1996 and 2018, we checked cases who suffered from non-thyroidal second primary cancers before, during, or after the diagnosis of thyroid cancer. Forty-nine patients met the criteria and were included in the study. The information was gathered from the medical records and supplemented by direct communication with the patients. The Data was then analyzed using appropriate statistical test with   SPSS version 22, considering a P-value of 0.05 was considered as significant.
Results: Out of the 2638 checked records reviewed, 49 patients (1.85%) were found to have second primary cancers with 75.5% being female. One patient had two concurrent second primary cancers, while the remaining 48 patients had a single second primary cancer. Most of the thyroid cancers were papillary (89.8%, 44 cases), with the others remaining cases being follicular type. Stage 2, according to the 8th AJCC staging system, was the most common (50%), followed by stage 1 (36.8%) among the primary staging categories. Breast cancer was the most prevalent (17 cases), followed by hematologic malignancies (8 cases) and GI tract cancers (8 cases). 
Conclusion: The findings revealed a significant increase in the number of breast cancers in patients with the differentiated thyroid cancer (DTC), which was not observed for other malignancies.
کلیدواژه‌های انگلیسی مقاله Differentiated thyroid cancer, Second primary cancer, Tumor staging, Malignancy
نویسندگان مقاله Sajjad Sadeghpour |
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Seyed Rasoul Zakavi |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Emran Askari |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Forough Kalantari |
Department of Nuclear Medicine, Rasoul Akarm Hospital, Iran University of Medical Sciences, Tehran, Iran

Reza Karimi |
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Zakieh Nasiri |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Susan Shafiei |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Ehsan Soltani |
Oncologic Surgery Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Atena Aghaee |
Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Amin Doostparast |
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40371_dc955042f6ee524600d0ea1e6e3254e4.pdf
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