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Iranian Journal of Nuclear Medicine، جلد ۳۳، شماره ۱، صفحات ۵۴-۶۰
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عنوان انگلیسی The utility of [18F]FDG PET/CT in children with neurofibromatosis type 1: A retrospective single-center study
چکیده انگلیسی مقاله Introduction: Neurofibromatosis type 1 (NF1) is a prevalent inherited condition, having a risk for malignant conversion to malignant peripheral nerve sheath tumor (MPNST). Our study objective was to assess the effectiveness of [18F]FDG PET/CT and Magnetic Resonance Imaging (MR) in identifying early transformation in pediatric patients, given the limited data available in existing literature.
Methods: In this study children with suspected or confirmed NF1 who underwent [18F]FDG between January 2007 and April 2024 were included in a retrospective cross-sectional analysis. Exclusion criteria was follow-up periods shorter than one-year post [18F]FDG results.
Results: The study included 13 patients (6 females, 7 males), with a median age of 11 years, and a total of 16 lesions. Only two lesions were confirmed by biopsy to have undergone malignant transformation into a MPNST. Although the findings varied, [18F]FDG imaging was able to anticipate the malignant transformation only in one of these two cases.
Conclusions: Due to the limited sample size, definitive conclusions could not be provided. We were unable to propose a specific SUVmax cutoff to predict the malignant transformation of neurofibromas in children with NF1  disease.
کلیدواژه‌های انگلیسی مقاله Neurofibromatosis type 1, [18F]FDG PET/CT, MRI, Malignant transformation, Malignant peripheral nerve sheath tumor, Neurofibroma
نویسندگان مقاله Armaghan Fard-Esfahani |
Diagnostic Imaging Department, The Hospital for Sick Children, Toronto, Canada

Riyadh AlSalloum |
Medical Imaging Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Govind Chavhan |
Diagnostic Imaging Department, The Hospital for Sick Children, Toronto, Canada

Amer Shammas |
Diagnostic Imaging Department, The Hospital for Sick Children, Toronto, Canada

Afsaneh Amirabadi |
Diagnostic Imaging Department, The Hospital for Sick Children, Toronto, Canada

Reza Vali |
Diagnostic Imaging Department, The Hospital for Sick Children, Toronto, Canada

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40379_c647feca953b156b6706e8d1f8ed10a5.pdf
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