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Iranian Journal of Basic Medical Sciences، جلد ۲۸، شماره ۱، صفحات ۳-۱۵
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عنوان انگلیسی Regulatory role of circular RNAs in the development of therapeutic resistance in the glioma: A double-edged sword
چکیده انگلیسی مقاله Gliomas are the most common lethal tumors of the brain associated with a poor prognosis and increased resistance to chemo-radiotherapy. Circular RNAs (circRNAs), newly identified noncoding RNAs, have appeared as critical regulators of therapeutic resistance among multiple cancers and gliomas. Since circRNAs are aberrantly expressed in glioma and may act as promoters or inhibitors of therapeutic resistance, we categorized alterations of these specific RNAs expression in therapy resistant-glioma in three different classes, including chemoresistance, radioresistance, and glioma stem cell (GSC)-regulation. circRNAs act as competing endogenous RNA, sponging target microRNA and consequently affecting the expression of genes related to glioma tumorigenesis and resistance. By doing so, circRNAs can modulate the critical cellular pathways and processes regulating glioma resistance, including DNA repair pathways, GSC, epithelial-mesenchymal transition, apoptosis, and autophagy. Considering the poor survival and increased resistance to currently approved treatments for glioma, it is crucial to increase the knowledge of the resistance regulatory effects of circRNAs and their underlying molecular mechanisms. Herein, we conducted a comprehensive search and discussed the existing knowledge regarding the important role eof circRNAs in the emergence of resistance to therapeutic interventions in glioma. This knowledge may serve as a basis for enhancing the effectiveness of glioma therapeutic strategies.
کلیدواژه‌های انگلیسی مقاله Cancer therapy, Chemoresistance, CircRNAs, Drug resistance, Glioblastoma, Glioma, Noncoding RNA, Radioresistance
نویسندگان مقاله | Negin Masoomabadi
Department of Neuroscience and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


| Ali Gorji
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran|Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran|Epilepsy Research Center, Münster University, Münster, Germany


| Tahereh Ghadiri
Department of Neuroscience and Cognition, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran


| Safieh Ebrahimi
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran|Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
نشانی اینترنتی https://ijbms.mums.ac.ir/article_25003.html
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نوع مقاله منتشر شده Review Article
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