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Avicenna Journal of Phytomedicine، جلد ۱۵، شماره ۱، صفحات ۸۹۰-۹۰۶
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Anti-oxidant and anti-apoptotic effects of gamma-oryzanol on male reproductive function in chronic restraint stress in rats
چکیده انگلیسی مقاله Objective: This study investigates the effects of GO on depressive behaviors and reproductive parameters in rats exposed to CRS.Materials and Methods: Rats were divided into three groups: sham, CRS-control, and CRS-GO. Behavioral assessments using the SPT and measurements of body and testes weights were conducted. Reproductive potential was evaluated by ELISA for testosterone, LH, and FSH levels, as well as sperm characteristics. Oxidative stress levels were assessed through MDA measurements and antioxidant enzyme activities. Additionally, apoptotic and signaling pathway proteins were analyzed by measuring cleaved caspase-3 and Nrf-2 levels in the testes using western blot analysis. Results: GO mitigated depressive behaviors and reduced serum corticosterone levels compared to the CRS-control group. GO increased testosterone, LH, and FSH levels and improved sperm parameters. GO supplementation reduced MDA levels and enhanced antioxidant enzyme activities compared to the CRS-control group. The analysis showed that GO down-regulated cleaved caspase-3 levels and up-regulated Nrf-2 protein levels in the testes of CRS rats compared to the CRS-control group. Conclusion: The administration of GO treatment can contribute to the recovery from male reproductive complications by regulating oxidative stress and apoptotic pathways.
کلیدواژه‌های انگلیسی مقاله Gamma-oryzanol, Chronic restraint stress, Sperm Parameters, Apoptosis, Oxidative stress
نویسندگان مقاله | Mahsan Alizadeh
Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran


| Sina Moshtagh
Department of Clinical Science, Theriogenology Section, School of Veterinary Medicine, Razi University, Kermanshah, Iran


| Shahabaddin Abdolalizadeh Amir
Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran


| Mostafa Jeddi
Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran


| Sepehr Tahmasebzadeh
Department of Clinical Sciences, Faculty of Veterinary Medicine, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran


| Ghazal Radman
Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran


| Amin Bagheri
Department of Urology, Sina Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.


| Yasin Bagheri
Kidney Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran


| Nazanin Shahabinejad
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_24819.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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