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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۹، شماره ۱، صفحات ۳۷-۴۲
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عنوان انگلیسی Minimal Residual Disease in Acute Lymphoblastic Leukaemia and Its Relationship with Other Prognostic Factors
چکیده انگلیسی مقاله Background: Minimal Residual Disease (MRD) assessment is crucial for directing treatment decisions in Acute Lymphoblastic Leukemia (ALL). In low- and middle-income countries, limited resources can present challenges to implementing MRD-guided therapy intensification for ALL. The study attempted to assess the relationship between MRD and other prognostic factors in ALL, focusing on treatment outcomes and disease progression. Materials and Methods: A retrospective observational study was conducted at Ramaiah Medical College and Hospital in Bengaluru, examining patient data from January 2021 to December 2021. MRD status was determined post-induction using flow cytometry. Patients were classified into various groups based on factors such as type of ALL (B-cell or T-cell), NCI risk status (standard or high), cytogenetic risk (favorable, poor, or intermediate), CNS status, prednisone response, and MRD levels at the end of induction. Results: Out of 72 patients, 25% were MRD-positive, with a male: female ratio of 2.13:1. B-ALL was diagnosed in 49 patients and T-ALL in 23, with 75% categorized as high-risk by NCI criteria. Cytogenetic analysis revealed a diverse profile (23.61% PR, 48.61% IR, 27.78% FR), and 58.33% exhibited a good prednisone response (GPR). At the end of the induction phase, 25% tested positive for MRD, with B-ALL showing a lower MRD rate at 15.2%. Age and NCI risk status significantly influenced MRD outcomes, with 75% of participants classified as high-risk. Conclusion: This study demonstrates a significant association between MRD positivity and factors such as age, NCI risk status, and B-ALL diagnosis, underscoring the complex interaction of these variables in predicting treatment outcomes for ALL patients.
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نویسندگان مقاله | Chinmayee Agrawal
Department of Medical Oncology, Ramaiah Medical College, Bengaluru, India


| Sai Boppana
Department of Medical Oncology, NRI Medical College and Hospital, Mangalagiri, Andhra Pradesh, India


| Santhosh Devdas
Department of Medical Oncology, Ramaiah Medical College, Bengaluru, India


| Vinayak Maka
Department of Medical Oncology, Ramaiah Medical College, Bengaluru, India


| Nalini Kilara
Department of Medical Oncology, Ramaiah Medical College, Bengaluru, India


| Swaratika Majumdar
Department of Medical Oncology, Ramaiah Medical College, Bengaluru, India


| Rasmi Palassery
Department of Medical Oncology, Ramaiah Medical College, Bengaluru, India
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2095
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