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Iranian Journal of Microbiology، جلد ۱۷، شماره ۲، صفحات ۳۰۳-۳۱۱
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عنوان انگلیسی Antifungal effect of soil Bacillus bacteria on pathogenic species of the fungal genera Aspergillus and Trichophyton
چکیده انگلیسی مقاله Background and Objectives: The increasing prevalence of fungal infections due to antifungal resistance underscores the need for novel treatment strategies. The present study aimed to investigate the inhibitory effects of soil-originated antagonistic bacteria against Aspergillus and Trichophyton species. Materials and Methods: Fifty soil samples collected from Isfahan and Khuzestan provinces by using the Zig-Zag method were cultured on glucose-yeast extract (GY) agar around fungal colonies to isolate antagonistic bacteria. Antifungal activity was assessed by measuring clear zones around the colonies of A. niger, A. fumigatus, T. rubrum, and T. mentagrophytes by co-culture linear method. Potent antagonistic bacteria were identified by 16S rRNA sequencing, and evaluated for antifungal activity using disk diffusion assays compared with amphotericin B and ketoconazole. Results: Among 50 samples, fifteen showed antifungal effects, yielding 55 bacterial strains. Four isolates with strong antifungal activity against all tested fungi were identified as Bacillus subtilis, B. licheniformis, B. axarquiensis, and Bacillus sp. These bacteria were distributed in distinct clusters phylogenitically and showed diverse antifungal activity. Conclusion: The results suggest the potential of soil-derived Bacillus species as promising antifungal agents. Further studies are recommended to identify their inhibitory metabolites, their ability as biocontrol agents against soil habitated fungi and to explore their mechanism of action and spectrum of activity.
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نویسندگان مقاله | Mahnour Taghavi
Department of Microbiology, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran


| Maryam Ahmadi
Department of Microbiology, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran


| Davoud Dehghan-Nayeri
Department of Microbiology, Faculty of Pharmacy, Islamic Azad University, Tehran, Iran


| Zahra Salehi
Department of Mycology, Pasteur Institute of Iran, Tehran, Iran


| Masoomeh Shams-Ghahfarokhi
Departmentt of Mycology, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran


| Fatemehsadat Jamzivar
Department of Mycology, Pasteur Institute of Iran, Tehran, Iran


| Mehdi Razzaghi-Abyaneh
Department of Mycology, Pasteur Institute of Iran, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5092
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