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Medical Laboratory Journal، جلد ۱۸، شماره ۶، صفحات ۰-۰
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عنوان انگلیسی Association of Vitamin D with Oxidative stress in patients with Type 2 diabetes mellitus
چکیده انگلیسی مقاله Background: Type2 Diabetes mellitus (T2DM) is non communicable disease including hyperinsulinemia, insulin resistance, hyperglycemia and low grade chronic inflammation associated with  various micro and macro vascular complications  .
Objectives: The present study aimed to estimate the  Vitamin D  , total antioxidant capacity and Malondialdehyde (MDA) levels in T2DM patients compared with healthy volunteers, further to find out  vitamin D association between HbA1c, total antioxidant capacity , MDA, lipid profile levels
 Materials and methods: Seventy type 2 diabetic patients with age group of 35 to 50 years were selected and 70 healthy age matched subjects were selected as controls. Serum Vitamin D and Insulin was estimated by ELISA, Glycosylated hemoglobin (HbA1C) was assessed by HPLC method and other routine lipid profile investigations carried out by Beckman Coulter fully automated analyzer.
Results:  Vitamin D levels were significantly decreased in type 2 diabetic patients.  HbA1C and insulin resistance values are significantly increased in type 2 diabetic patients. Vitamin D levels Negatively correlated with MDA, insulin resistance , HbA1c  and positively correlated with total antioxidant capacity . But there is no significant correlative changes observed between lipid profile parameters.
Conclusion:  Vitamin D deficiency may be one of the vital risk factor responsible for increased oxidative stress in T2DM patients.  Regular monitoring and supplementation of vitamin D beneficial for reduction of oxidative stress and vascular complications in T2DM patients.
 
کلیدواژه‌های انگلیسی مقاله Type 2 diabetes mellitus (T2DM), Vitamin D (Vit D) , Insulin resistance evaluation (IR)
نویسندگان مقاله | Balu Mahendran Kanumuru
Assistant professor, Department of Biochemistry, Siddartha medical college, Vijayawada, Andhrapradesh, India.


| Sridevi Nutakki
Professor, Department of Biochemistry, Siddartha medical college, Vijayawada, Andhrapradesh, India
نشانی اینترنتی http://mlj.goums.ac.ir/browse.php?a_code=A-10-1505-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Research Article
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