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Molecular Biology Research Communications، جلد ۱۴، شماره ۳، صفحات ۲۴۳-۲۴۸
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عنوان انگلیسی Expression patterns of circRFX3 and miR-587 in colorectal cancer patients
چکیده انگلیسی مقاله Circular RNAs (circRNAs) are non-coding, single-stranded RNAs considered by their closed-loop structures. Research has established a connection between circRNAs and cancer progression. The objective of this project was to evaluate the expression levels of a newly discovered circRNA, circRFX3 (hsa_circRFX3_003), along with its target gene, miR-587. The study involved 60 patients diagnosed with Colorectal cancer (CRC) and 60 healthy individuals as controls. Total RNA was extracted from blood samples, converted into cDNA, and analyzed using qRT-PCR. The findings revealed an up-regulation of miR-587 and a down-regulation of circRFX3 in the blood samples of CRC patients. An inverse relationship was observed between the levels of miR-587 and circRFX3; however, there was no significant difference in circRFX3 expression levels between stages I+II and stages III+IV. The levels of miR-587 expression were linked to tumor size and location. Both circRFX3 and miR-587 play significant roles in the pathophysiology of CRC; however, additional research is necessary to elucidate their specific contributions to CRC development.    
کلیدواژه‌های انگلیسی مقاله circRFX3,miR-587,CRC,Gene expression,Real-time PCR
نویسندگان مقاله Samaneh Najafi |
Department of Biology, University Campus 2, University of Guilan, Rasht, Iran

Zivar Salehi |
Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Farhad Mashayekhi |
Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Hamid Saidi-Saedi |
Department of Internal Medicine, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

نشانی اینترنتی https://mbrc.shirazu.ac.ir/article_8027_fc74b765e3ce0720227387e57a62acc4.pdf
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