این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Parasitology، جلد ۱۲، شماره ۱، صفحات ۶۹-۸۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The 33.1 kDa Excretory/secretory Protein Produced by Toxo-cara canis Larvae Serves as a Potential Common Biomarker for Serodiagnosis of Toxocariasis in Paratenic Animals and Human
چکیده انگلیسی مقاله Background: Toxocariasis is a prevalent zoonosis disease caused by the closely related nematode species Toxocara canis and Toxocara cati which parasitise Canidae and Felidae respectively. In paratenic hosts, larvae of these worms cause multiple organ damage. However, how these paratenic hosts response to these worms and whether any common biomarker can be applied for diagnosis are still unclear. Methods: Excreted/secreted (E/S) antigens were prepared by culture of T. canis larvae in vitro. Using a western blot (WB) assay the humoral IgG responses, induced by Toxocara spp. larvae to the worm’s E/S antigens in different infected hosts including mice, rabbits and human, were examined. Results: In a mouse model of toxocariasis, intraperitoneal injection of T. canis larvae induces inflammatory leukocyte accumulation in the liver and the lungs but not in the brain, although a remarkable number of larvae were detected in this organ. Mice and rabbits responded differently to Toxocara spp. resulting in distinct heterogenous WB band patterns. Mice and rabbits both responded to a 33.1 kDa E/S constituent that turned out to be the most sensitive protein for serodiagnosis. Sera from human toxocariasis patients showed heterogenous WB band patterns similar to those observed in rabbits and all responded to the 33.1 kDa band. Conclusion: 33.1 kDa E/S protein can be considered as a critical common biomarker for toxocariasis immuno-diagnosis in both paratenic animals and human and its specificity requires further investigation.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله huu هانگ nguyen | huu hung nguyen
institute of tropical biology, vietnam academy of science and technology vast , ho chi minh, vietnam


doan trung vo | doan trung vo
nguyen tat thanh university, ho chi minh, vietnam


thi tuyet trinh thai | thi tuyet trinh thai
nguyen tat thanh university, ho chi minh, vietnam


thi thanh thao le | thi thanh thao le
nguyen tat thanh university, ho chi minh, vietnam


thanh دانک le | thanh dong le
institute of malariology, parasitology and entomology, ho chi minh, vietnam


nghia son hoang | nghia son hoang
institute of tropical biology, vietnam academy of science and technology vast , ho chi minh, vietnam
نشانی اینترنتی http://ijpa.tums.ac.ir/index.php/ijpa/article/view/1520
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/69/article-69-349950.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article(s)
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات