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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Cytogenetic abnormalities in myelodysplastic syndromes – a revisit.
چکیده انگلیسی مقاله Karyotype is one of the main constituents of the International Prognostic Scoring System (IPSS) and revised-IPSS that are the cornerstones for the prognostication of patients with myelodysplastic syndromes (MDS). Del(5q), –7/del(7q), +8 and –Y are among the most common cytogenetic abnormalities noted in MDS and the prognostic impact they have has been extensively studied. The same applies for normal karyotype. There are hundreds of other rare cytogenetic abnormalities that have been reported in MDS, included but not limited to –X, 3q abnormalities, +13/del(13q), i(17q), +21/–21. However, due to a very low number of patients, their impact on the prognosis of MDS is limited. Worldwide collaboration among hematologists may help expanding patient numbers for these rare cytogenetic abnormalities to allow for scientific studies with adequate sample size. Knowledge of the molecular consequences of the common cytogenetic abnormalities allows us to modify treatment regimens based on the agents most active against the specific karyotype present, allowing for the opportunity to individualize MDS treatment for each patient.
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نویسندگان مقاله محمد faizan زاهد | mohammad faizan zahid
medical graduate, aga khan university, karachi, pakistan.


umair ارشد مالک | umair arshad malik
medical graduate, aga khan university, karachi, pakistan.


momena سهیل | momena sohail
medical graduate, aga khan university, karachi, pakistan.


عرفان نظیر حسن | irfan nazir hassan
medical graduate, aga khan university, karachi, pakistan.


سارا علی | sara ali
medical graduate, aga khan university, karachi, pakistan.


محمد حمزه سعد shaukat | muhammad hamza saad shaukat
medical graduate, aga khan university, karachi, pakistan.
نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/582
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