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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰۱۵، شماره ۱۰، صفحات ۰-۰
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عنوان انگلیسی Cytogenetic abnormalities with interphase FISH method and clinical manifestation in Chronic Lymphocytic Leukemia patients in north east of Iran
چکیده انگلیسی مقاله Abstract: BACKGROUND: Chronic lymphocytic leukemia (CLL) is one of the most prevalent adult leukemias . This malignancy is known by lymphocytosis for duration of more than 3 months. In fact; it is a heterogeneous clinical disease with changeable progression . Chromosomal aberrations are significant parameters to predict the result and survival rate and find treatment strategies for each patient . Cytogenetic methods are known as sensitive and relatively new procedures to detect abnormalities in the genome . METHODS: In order to identify CLL related chromosomal abnormalities, 48 CLL patients include 38 Men and 10 Women with mean age of 58.25±36 were enrolled in this case- control study, which was done in Cancer Molecular Pathology Research Center of Mashhad University of medical sciences. 5 milliliters peripheral blood were cultured in RPMI; Del 17p, Del 13q Del 11q, Del6q21 and trisomy 12 were evaluated by Interphase FISH method. RESULTS: Analysis demonstrated that 45.5% of CLL cases have chromosomal abnormalities; 13.63% of patients have Del 17p, 40.90% Del 13q and 9.09% Del 11q. Statistical analysis of patients data revealed a significant relevancy between age variable and splenomegaly occurrence (P value< 0.05). The younger the patients were the less the splenomegaly. CONCLUSION Laboratory findings were correlated with clinical data.
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نویسندگان مقاله حسین رحیمی | hossein rahimi
md, associate professor of internal medicine, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

حسین آیت اللهی | hossein ayatollahi
md, associate professor of hematopathology, cancer molecular pathology research center , department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد هادی صادقیان | mohammad hadi sadeghian
md, associate professor of hematopathology, cancer molecular pathology research center , department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد رضا کرامتی | mohammad reza keramati
md, professor of hematopathology, cancer molecular pathology research center, department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امیر حسین جعفریان | amir hossein jafarian
md, associate professor of hematopathology, department of pathology, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سپیده شاکری | sepide shakeri
msc. cancer molecular pathology research center, department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

آرزو shajiee | arezoo shajiee
msc. cancer molecular pathology research center, department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

سیده فاطمه شمس | seyyede fatemeh shams
msc. cancer molecular pathology research center, department of hematology and blood bank, faculty of medicine, mashhad university of medical sciences, mashhad, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/609
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