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International Journal of Pediatrics، جلد ۱۲، شماره Issue ۳ (In Progress)، صفحات ۱۸۶۳۷-۱۸۶۴۸
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عنوان انگلیسی Associations between Prenatal Exposure to Air Pollutants and Cord-Blood Thyroid Hormones Levels: A Cross-Sectional Study in Isfahan
چکیده انگلیسی مقاله Background: Air pollution as a major health concern in the world can adversely affect pregnant women and their newborns' thyroid function. We evaluated the association between prenatal exposure to air pollutants and cord-blood thyroid hormone levels.Method: This cross-sectional study was conducted as a sub-study of the PERSIAN birth cohort on mothers and their newborns from October 2019 to September 2021. All participants, related data, and cord blood samples were gathered from the Isfahan. The air quality index (AQI), extracted from its official website, and was used to assess overall air quality during pregnancy. The association between mean levels of AQI in the three trimesters with cord blood thyroid hormone levels was evaluated.Results: In 195 mothers with a mean age of 29.79(5.46), the mean of TSH and free T4 was 6.96 IU/L and 1ng/dl, respectively. The total days with moderate AQI (51-100) were higher than other AQI categories over the three trimesters. This study found no significant association between the mean cord-blood TSH and AQI>100, (P>0.05). The mean cord-blood FT4 had a negative association with total unhealthy days for sensitive groups in the first trimester and total very unhealthy days in the third trimester. The mean cord-blood FT4 was positively associated with unhealthy days in the second trimester.Conclusion: The cord-blood FT4 levels were associated with prenatal exposure to AQI higher than 100. These results highlight the need for air pollution management to minimize neonatal thyroid hormone alteration and its critical sequelae.
کلیدواژه‌های انگلیسی مقاله Air pollution, air quality, maternal exposure, thyroid stimulating hormone
نویسندگان مقاله | Elaheh Gholverdi
Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Mahin Hashemipour
1. Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.


| Silva Hovsepian
Metabolic Liver Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran


| Mehri Khoshhali
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran


| Roya Kelishadi
Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
نشانی اینترنتی https://ijp.mums.ac.ir/article_24654.html
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