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Iranian Journal of Medical Sciences، جلد ۴۱، شماره ۲، صفحات ۱۰۲-۰
عنوان فارسی
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عنوان انگلیسی Effects of Sesame Butter (Ardeh) versus Sesame Oil on Metabolic and Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats
چکیده انگلیسی مقاله Background: Diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. Given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats. Methods: Forty male albino rats of Wistar strain were randomly divided into 4 groups (i.e., nondiabetic control rats, diabetic rats, diabetic rats treated with sesame butter, and diabetic rats treated with sesame oil). Experimental diabetes was induced with an intraperitoneal injection of streptozotocin (55 mg/kg). Sesame butter (1.25 g/kg) and sesame oil (0.5 g/kg) were given by oral gavage to the diabetic rats for 6 weeks. Finally, serum glucose, lipid profile, total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were measured and analyzed statistically. Results: Our data showed that the diabetic groups treated with sesame butter and sesame oil had significantly lower levels of glucose and higher levels of high-density lipoprotein than did the diabetic control group at the end of the study (P< 0.05). Sesame butter supplementation also increased TAC and decreased MDA concentrations significantly in the diabetic rats (P< 0.05). Conclusion: The antihyperglycemic, antioxidative, and partly lipid-lowering effects of sesame butter make it an excellent candidate for future human studies on diabetes, although further research is needed to determine the exact dose and duration of supplementation.
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نویسندگان مقاله فاطمه حیدری | fatemeh haidari
nutrition and metabolic diseases research center, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

مجید محمدشاهی | majid mohammadshahi
hyperlipidemia research center, ahvaz jundishapur university of medical sciences, ahvaz, iran;

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

مهدی زارعی | mehdi zarei
department of food hygiene, faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه شهید چمران (Shahid chamran university)

زهرا گرجی | zahra gorji
department of nutritional science, arvand international division of ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

نشانی اینترنتی http://ijms.sums.ac.ir/index.php/IJMS/article/view/855
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-350719.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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