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Iranian Journal of Parasitology، جلد ۲۰، شماره ۲، صفحات ۲۲۷-۲۳۵
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عنوان انگلیسی Evaluation of Toxoplasma and Toxocara Prevalence in Chronic Kidney Disease (CKD) Patients Using Serologic and Molecular Technique in Selected Medical Centers of Tehran, Iran
چکیده انگلیسی مقاله Background: Toxoplasmosis and toxocariasis are two zoonotic diseases with global impact. Chronic kidney disease (CKD) can lead to complications, associated with reduced immune responses that predispose them to frequent parasitic infections. We aimed to determine the prevalence of toxoplasmosis and toxocariasis in CKD patients to propose a new way to control them in dialyses duration in Tehran, Iran. Methods: Three hundred and sixty-five CKD patients and 72 healthy individuals were tested for anti-Toxoplasma gondii (IgG, IgM) and anti-Toxocara (IgG) antibodies using conventional ELISA technique. IgM positive samples underwent genetic analysis. Results: Of the 437 samples studied (365 patients and 72 controls), 182 CKD patients (49.8%) and 20 controls (27.9%) were positive for Toxoplasma IgG, and 8 (2.2%) CKD samples were positive for Toxoplasma IgM, while none of the control samples were positive for Toxoplasma IgM. Molecular analysis of the 8 IgM positive samples with B1gene confirmed the presence of Toxoplasma antigen in all of them. Toxocara IgG antibodies showed a lower prevalence in CKD patients (5.7%) compared to controls (9.7%). The study revealed significant differences (P <0.05) in Toxoplasma IgG and IgM antibodies, as well as variables such as dialysis and dialysis duration between the two groups of patients and the control group. However, variables such as Toxocara IgG, age, gender, lupus, and pets showed no significant difference between the control group and the patients. Conclusion: The collected data in this study could serve as a reference for future studies and may be useful for examination and evaluation of acute and chronic toxoplasmosis before and after starting dialysis.
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نویسندگان مقاله | Bahare Razmand
Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran


| Farid Tahvildar Biderouni
Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran


| Alireza Abadi
Department of Social Medicine School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran


| Niloofar Taghipour
1. Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran 2. Department of Social Medicine School of Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran 3. Department of Tissue Engineering and Applied Cell Science, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences Tehran, Iran
نشانی اینترنتی https://ijpa.tums.ac.ir/index.php/ijpa/article/view/4352
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