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Iranian Journal of Medical Sciences، جلد ۵۰، شماره ۷، صفحات ۴۸۱-۴۹۱
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عنوان انگلیسی Impact of Sappan Wood Extract as Iron Chelator Adjuvant on Iron Concentration and Macrophage Polarization in Rat Spleen
چکیده انگلیسی مقاله Background: Iron accumulation in the spleen of thalassemia patients disrupts macrophage polarization, impairs immune function, and increases mortality. Sappan wood (Biancaea sappan L.) extract exhibits iron-chelating and immunomodulatory properties, making it a potential adjuvant with Deferiprone (DFP). This study aimed to assess the effects of Sappan wood extract (SWE) as a DFP adjuvant in rat models of iron overload. 
Methods: This experimental study was conducted from January to March 2024 at Padjadjaran University, Indonesia. Thirty-five rats were divided into seven groups: normal, iron overload (IO) induced by iron dextran (ID) at a cumulative dose of 60 mg/Kg body weight (BW), positive control receiving DFP, and four groups receiving DFP+SWE at different doses of 50, 100, 150, and 200 mg/Kg BW. Iron levels and macrophage polarization (pro-inflammatory M1 and anti-inflammatory M2) in the spleen were assessed. 
Results: SWE at 50 mg/Kg BW significantly reduced spleen iron levels to 60.77 ppm/mg and increased M2 intensity (P<0.001 compared to the IO group). At 100 mg/Kg BW, SWE effectively decreased M1 macrophage intensity (P=0.001 compared to the IO group).
Conclusion: SWE at 50 mg/Kg BW was comparable to DFP in reducing the spleen iron levels and M1 macrophage intensity, while 100 mg/Kg BW enhanced M2 macrophage polarization. These findings highlighted SWE’s potential as a therapeutic adjuvant in IO conditions. 
کلیدواژه‌های انگلیسی مقاله Deferiprone,Macrophage,iron overload,Iron chelating agents
نویسندگان مقاله Mohammad Ghozali |
Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Jatinangor, West Java 45363, Indonesia

Ratu Safitri |
Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor, West Java 45363, Indonesia

Erick Khristian |
Department of Biotechnology, Faculty of Postgraduate, Padjadjaran University, Bandung, West Java 45363, Indonesia

Amethyst Puspita Ainni |
Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor, West Java 45363, Indonesia

Yasmi Purnamasari Kuntana |
Department of Biology, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Jatinangor, West Java 45363, Indonesia

Muhamad Hasan Bashari |
Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Jatinangor, West Java 45363, Indonesia

Jeri Nobia Purnama |
Department of Biotechnology, Faculty of Postgraduate, Padjadjaran University, Bandung, West Java 45363, Indonesia

نشانی اینترنتی https://ijms.sums.ac.ir/article_50989_724070d67e7c8e9c6f7d328c624fbc92.pdf
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