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Physiology and Pharmacology، جلد ۲۹، شماره ۲، صفحات ۲۱۹-۲۳۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Stevia and especially Nano-Stevia induced anti diabetic, antidepressant, and analgesic effects in streptozotocin-induced diabetic rats
چکیده انگلیسی مقاله Introduction: Diabetes mellitus is a metabolic disease. This disease is almost associated with depression and impaired pain sensation. Stevia rebaudiana Bertoni (stevia) has a sweet taste and a useful effect in blood glucose control. This study was designed to evaluate the effect of Stevia and Nano-stevia on psychological problems (e.g. depression and pain) induced by diabetes.
Methods: By a single intraperitoneal administration of streptozotocin, diabetes mellitus was induced in male Wistar rats. Stevia (20 mg/dl per day for 30 days) and Nano-stevia (20 mg/dl per day for 30 days) were administrated intra-gastrically in diabetic rats. Using the forced swim test (FST) and formalin test, depression and pain behaviors were measured, respectively. 
Results: The results exhibited that male diabetic rats showed hyperglycemia, depressant-related behavior, and hyperalgesic response. On the other hand, intragastric usage of Stevia (20 mg/dl per day for 30 days) and Nano-stevia (20 mg/dl per day for 30 days) modified the hyperglycemia, depressant-related response, and hyperalgesic effect in diabetic rats. Nano-stevia indicated the maximum significant response rather than Stevia.
Conclusion: The results of this study indicate that Stevia and particularly Nano-stevia could be beneficial in managing diabetes and its associated behavioral complications.
کلیدواژه‌های انگلیسی مقاله Diabetes, Stevia, Nano-stevia, Depression-related behavior, Pain
نویسندگان مقاله | Neda Mousavi-Niri
Department of Biotechnology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Maryam Naseroleslami
Department of Cellular and Molecular Biology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Elham Ghanimati
Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran


| Marzieh Moheb-Alian
Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.


| Faezeh Abdollah-pour
Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.


| Fatemeh Khakpai
Department of Physiology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-496-5&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurophysiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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