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The Journal of Tehran University Heart Center، جلد ۱۰، شماره ۱، صفحات ۳۴-۴۲
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عنوان انگلیسی Introducing the Tehran Heart Center's Premature Coronary Atherosclerosis Cohort: THC-PAC Study
چکیده انگلیسی مقاله Background: Data on premature coronary artery disease (CAD) are scarce. The Tehran Heart Center's Premature Coronary Atherosclerosis Cohort Study (THC-PAC) is the first study of its kind in the Middle East to assess major adverse cardiac events (MACE) in young CAD patients. Methods: The cohort consists of CAD patients, males ≤ 45 years old and females ≤ 55 years old. The participants are residents of Tehran or its suburbs and underwent coronary angiography between June 2004 and July 2011. A 10-year follow-up, via either clinical visits or telephone calls at least once a year, was commenced in August 2012. The end point is considered MACE, encompassing death, myocardial infarction, stroke, new coronary involvement, percutaneous coronary intervention, and coronary artery bypass grafting. Results: The cohort comprises 1232 eligible patients (613 [49.8%] males) at a mean age of 45.1 years (SD = 5.8). High frequencies of conventional risk factors, including hyperlipidemia (884 [71.8%]), hypertension (575 [46.7%]), positive family history (539 [43.8%]), cigarette smoking (479 [38.8%]), and diabetes mellitus (390 [31.7%]), were seen in the participants. The mean body mass index (BMI) of the enrolled patients was high (29.2 ± 4.8 kg/m 2 ), and 532 (43.3%) and 440 (35.8%) of them were overweight and obese, respectively. The females’ BMI was higher (30.4 ± 5.3 vs. 28.0 ± 3.9 kg/m2; P < 0.001) and they had a greater mean abdominal circumference (99.9 ± 13.5 vs. 98.1 ± 9.3 cm; P = 0.035). Between August 2012 and August 2013, follow-up was successful in 1173 (95.2%) patients (median follow-up duration = 55.3 months, 95%CI: 53.5-57.0 months). Conclusion: Our younger patients with CAD had a high frequency of risk factors compared to the same-age general population and all-age CAD patients, which may predispose them to higher incidence of recurrent MACE.
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نویسندگان مقاله سید حسام الدین عباسی | seyedhesameddin abbasi
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سید ابراهیم کساییان | seyedebrahim kassaian
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سعید صادقیان | saeed sadeghian
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عباسعلی کریمی | abbasali karimi
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سهیل سعادت | soheil saadat
sina trauma research center, tehran university of medical sciences, tehran. iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فلورا پیوندی | flora peyvandi
fondazione irccs ca’ granda ospedale maggiore policlinico milano, angelo bianchi bonomi hemophilia and thrombosis centre, milan, italy and department of pathophysiology and transplantation, università degli studi di milano, milan, italy.


آرش جلالی | arash jalali
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

طاهره داورپسند | tahereh davarpasand
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نازیلا شاه منصوری | nazila shahmansouri
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

معصومه لطفی تکلدانی | masoumeh lotfi tokaldany
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مریم امیری ابچویه | maryam amiri abchouyeh
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فرح ayatollahzade اصفهانی | farah ayatollahzade isfahani
tehran heart center, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

frits rosendaal | frits rosendaal
department of clinical epidemiology and department of thrombosis and haemostasis, leiden university medical center, leiden, the netherlands.
نشانی اینترنتی http://jthc.tums.ac.ir/index.php/jthc/article/view/362
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