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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۹، شماره ۳، صفحات ۲۱۰-۲۱۴
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عنوان انگلیسی Immunocytochemical Detection of BCL-2 Protein in Chronic B-Cell Lymphoproliferative Disorders
چکیده انگلیسی مقاله Background: The expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) protein in B-cell chronic lymphoproliferative disorders (B-CLPDs) can provide valuable prognostic information and assist in assessing minimal bone marrow (BM) infiltration. This study aimed to detect BCL-2 expression in B-CLPDs and correlate the findings with various clinicobiologic factors. Materials and Methods: Immunocytochemical staining was performed on mononuclear cell smears from 46 Sudanese patients, including 25 with B-cell chronic lymphocytic leukaemia (B-CLL) and 21 with B-cell non-Hodgkin’s lymphomas (B-NHL), who were enrolled during their visit to the Radiation and Isotope Centre and Fedail Hospital, Khartoum. Diagnosis was based on clinical examination, morphology, and immunophenotyping. Results: Among the 46 B-CLPD cases, BCL-2 expression was identified in 13 (28.2%), including 8/25 (32%) cases with B-CLL and 5/21 (23.8%) with B-NHL. No statistically significant associations were found between BCL-2 expression and age, sex, total white blood cell count, disease stage, and serum lactate dehydrogenase levels (all P>0.05). However, BM involvement was significantly associated with BCL-2 expression (P=0.02). Conclusion: The immunocytochemical staining method effectively detects BCL-2 protein in B-CLPDs, even in cases with minimal BM infiltration, thereby facilitating the correlation of this protein’s expression with morphological and other clinicobiologic features. By combining cytologic morphology with immunocytochemistry, this technique enables earlier and more accessible evaluation of BM involvement.
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نویسندگان مقاله | Awad-Elkareem Abass
Faculty of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia


| Isra Babiker
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan


| Alaa Mohmmed
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan


| Remaz Hamza
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan


| Salma Albashir
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan


| Ohood Osman
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan


| Safa Abbas
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan


| Amna Idris
Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2193
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