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The Journal of Tehran University Heart Center، جلد ۲، شماره ۴، صفحات ۲۱۳-۲۱۶
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عنوان انگلیسی An Ovine Model of Dilated Cardiomyopathy Induced by Doxorubicin
چکیده انگلیسی مقاله Background: Dilated cardiomyopathy is associated with a progressive deterioration in cardiac function and eventually death. Initial interest in this hypothesis was to create another large animal model for dilated cardiomyopathy in addition to pigs and dogs . Methods: After the induction of anesthesia to 10 female sheep, a carotid-jugular shunt was created in all the animals via a 1-cm fistula between the carotid artery and jugular vein. Six sheep out of the total of 10, were given intravenous Doxorubicin. Echocardiographic studies were performed before surgery and 3 months after that. The 4 animals not injected with Doxorubicin were evaluated for echocardiographic parameters after one year . Results: There was no abnormality in echo parameters in the 4 sheep that had not received Doxorubicin; in addition, their valves and cardiac output were normal. As regards the six sheep injected with Doxorubicin, 4 received a dose of 2 mg/kg weekly and expired after the second injection due to the toxicity of the drug, 1 was given Doxorubicin 1 mg/kg and died after one week, and 1 had Doxorubicin 0.5 mg/kg but showed no abnormality in terms of dilated cardiomyopathy . Conclusion: We conclude that the sheep is sensitive to Doxorubicin and that the dosage that is enough for creating dilated cardiomyopathy in dogs is very toxic for the sheep.
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نویسندگان مقاله محمود میرحسینی | mahmood mirhoseini
tehran heart center, medical sciences university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

شهرام ربانی | shahram rabbani
tehran heart center, medical sciences university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

سیروس دارابیان | sirus darabian
tehran heart center, medical sciences university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

سعید صادقیان | saeed sadeghian
tehran heart center, medical sciences university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

عباسعلی کریمی | abbasali karimi
tehran heart center, medical sciences university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

سید حسام الدین عباسی | seyed hesameddin abbasi
tehran heart center, medical sciences university of tehran, tehran, iran.

سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)

نشانی اینترنتی http://jthc.tums.ac.ir/index.php/jthc/article/view/67
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زبان مقاله منتشر شده en
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