Material and Methods: In this experimental study, 42 male Wistar rats weighing 200 ± 220gr were divided into 6 groups: (n=7) as follows: control group, positive control group (silymarin, 100 mg/kg body weight, gavaged), sham group (received olive oil at the rate of 0.25 ml), CCl4 group (received carbon tetrachloride at the rate of 2 ml/kg of body weight, at a ratio of 1:1 with olive oil, ip), Treatment group 1 (receives of carbon tetrachloride + palm  meristem  extract, 250 mg/kg), treatment 2 (receives of carbon tetrachloride + palm  meristem  extract, 500 mg/kg) and  treatment 3 (carbon tetrachloride + palm  meristem  extract, 750 mg/kg). After the experiments, blood samples were collected and blood serum were separated and the serum levels of MDA, GSH and GPx and liver enzymes were analyzed . The liver tissue sample was separated and placed and prepared for histological studies. 

  Results: The results showed that carbon tetrachloride causes liver tissue necrosis in CCl4 group rats. The serum levels of AST, ALT and ALP enzymes in the CCl4 group increased compared to the control group (p<0.001). The serum levels of GSH and GPx in treatment groups increased significantly with CCL4 group (p<0.001). 

  Conclusion: The hydroethanolic extract of palm meristem due to its phenolic and antioxidant properties, is able to protect the liver tissue against the harmful effects of carbon tetrachloride and brings liver enzymes levels to normal.