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Acta Medica Iranica، جلد ۶۳، شماره ۵، صفحات ۲۶۷-۲۷۷
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عنوان انگلیسی Synergistic Effects of Bavachinin in Combination With Either Ezetimibe or Atorvastatin on Liver Biomarkers: A Randomized Controlled Trial in Hyperlipidemic Rats With NAFLD
چکیده انگلیسی مقاله Bavachinin, a flavonoid derived from Psoralea corylifolia, exhibits antioxidant and anti-inflammatory properties and functions as a pan-agonist of PPAR nuclear receptors. This study aimed to evaluate the individual and combined effects of bavachinin with either ezetimibe or atorvastatin on liver function markers and hepatocyte apoptosis in a rat model of diet-induced hyperlipidemia. Thirty-five male Wistar rats were randomly assigned to seven groups: normal control (NC), hyperlipidemic control (HC), bavachinin (BAV), atorvastatin (ATV), ezetimibe (EZI), ATV+BAV, and EZI+BAV. Hyperlipidemia was induced in all groups except NC. Serum levels of AST, ALT, ALP, and IL-10 were measured before and after the 4-week intervention period. Liver tissue was assessed using TUNEL staining. Wilcoxon signed-rank tests showed significant within-group reductions in AST in all intervention groups (P<0.05). ALT significantly decreased in the BAV and ATV+BAV groups. IL-10 levels significantly increased in the EZI, BAV, ATV+BAV, and EZI+BAV groups. Kruskal-Wallis ANOVA revealed significant between-group differences in AST, ALT, and IL-10 levels across all groups (P<0.05). Post hoc Mann-Whitney U tests revealed that both combination groups (ATV+BAV and EZI+BAV) showed significant reductions in AST levels compared with the HC group, and the EZI+BAV group also demonstrated a significant reduction in ALT. IL-10 levels exhibited significant improvements in both combination groups compared with BAV alone. Additionally, TUNEL staining indicated reduced hepatocyte apoptosis in both combination groups as well as in the BAV group relative to the HC group. Bavachinin, in combination with ezetimibe or atorvastatin, demonstrated hepatoprotective and anti-inflammatory effects in a rat model of fatty liver disease. These findings suggest potential therapeutic roles for bavachinin. However, further studies, including complete lipid profiling and oxidative stress markers, are needed.
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نویسندگان مقاله | Seyed Amirhadi Hosseini
Abdolvahabi7, Hossein Piri8* 1 Student Research Committee, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.


| Yazdan Naderi
Department of Pharmacology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.


| Seyedalireza Mirilavasani
Health Food Innovation Management, Maastricht University, Campus Venlo, Venlo, The Netherlands.


| Frits van Osch
Department of Clinical Epidemiology, VieCuri Medical Centre, Venlo, The Netherlands. AND Department of Epidemiology, NUTRIM School for Nutrition and Metabolism, Maastricht University, Maastricht, The Netherlands .


| Rasoul Samimi
Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.


| Zohreh Abdolvahabi
Department of Biochemistry and Genetics, Qazvin University of Medical Sciences, Qazvin, Iran .


| Hossein Piri
Non-communicable Diseases Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran .
نشانی اینترنتی https://acta.tums.ac.ir/index.php/acta/article/view/11732
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