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Iranian Journal of Microbiology، جلد ۱۷، شماره ۶، صفحات ۱۰۴۹-۱۰۵۸
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عنوان انگلیسی A comparative study on proinflammatory cytokines interleukin-17A and interleukin-17F expressions in whole blood of patients with COVID-19
چکیده انگلیسی مقاله Background and Objectives: Coronavirus disease 2019 (COVID-19), due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has expanded rapidly to all over the world. Interleukin-17 is one of the inflammatory cytokines which is highly expressed in the blood of individuals with COVID-19. Our aim in the present survey was to assess the mRNA expression levels of cytokine IL-17A, IL-17F and TNF-α in the blood of COVID-19 patients compared with healthy control individuals. Materials and Methods: A total of 69 patients including 32 mild patients, 20 severe and 17 asymptomatic patients in comparison with 25 healthy controls were evaluated. To measure the expression profile of IL-17A and IL-17F in whole blood, quantitative PCR was used. Results: Asymptomatic, mild, and severe SARS-CoV-2 infections were found to have significantly higher levels of IL-17A and IL-17F mRNAs than the healthy group (fold change IL-17A: 3.778; p= 0.002, 4.003; p= 0.001, 2.608; p= 0.0001 respectively, fold change IL-17F: 2.967; p= 0.003, 3.819; p= 0.001, 2.617; p= 0.0012 respectively). TNF-α mRNA expression was also measured, which shows an approximately similar increase compared to IL-17 (fold change: 2.726; p= 0.002, 2.383; P= 0.001, 2.631; p= 0.001, respectively). Conclusion: SARS-CoV-2 infection severity was associated with blood levels of IL-17A and IL-17F mRNA.
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نویسندگان مقاله | Zeynab Rahni
Department of Molecular Virology, Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran


| Seyed Reza Mohebbi
Department of Medical Virology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Seyed Masoud Hosseini
Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran


| Shahrzad Shoraka
Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran


| Kambiz Nabati
Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, Iran


| Mahsa Saeedi Niasar
Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Shabnam Shahrokh
Department of Medical Virology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Amir Sadeghi
Department of Medical Virology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Reza Zali
Department of Medical Virology, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
نشانی اینترنتی https://ijm.tums.ac.ir/index.php/ijm/article/view/5009
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