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Physiology and Pharmacology، جلد ۲۹، شماره ۴، صفحات ۴۲۴-۴۳۸
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عنوان انگلیسی A new accessible source of endometrial mesenchymal stem cells: a promising strategy for liver regeneration and repair in a rat model of chemotherapy-induced injury
چکیده انگلیسی مقاله Introduction: Alkylating agents, commonly used in chemotherapy, can cause significant liver damage by inducing cell death pathways. Human menstrual blood-derived mesenchymal stem cells (HuMenSCs), with their remarkable proliferative capacity and easy accessibility, offer a potential treatment for this injury. Methods: We investigated the impact of transplanting HuMenSCs in rats using a liver damage model caused by Busulfan injection (36 mg/kg, i.p.). Engraftment was confirmed using fluorescence microscopy and flow cytometry. Hepatic morphology was assessed via histopathological examination. Apoptosis was quantified by TUNEL assay and real-time PCR analysis of apoptotic (Bax) and anti-apoptotic (Bcl2) gene expression. Results: HuMenSCs effectively engrafted into injured liver tissue. Histopathological examination revealed hepatic morphology significantly improved in the group treated with HuMenSCs, with reduced inflammation, congestion, and sinusoidal dilation. Additionally, both the TUNEL assay and real-time PCR analysis demonstrated a significant decrease in apoptosis and a shift toward the downregulation of pro-apoptotic gene expression (Bax) in the group that received HuMenSCs treatment when compared with the sham (p < 0.0001) and negative control groups (p < 0.001). Conclusion: The results of our research suggest that HuMenSCs transplantation effectively mitigates Busulfan-induced liver injury by inhibiting apoptosis and promoting liver regeneration. These findings demonstrate the promise of HuMenSCs as a novel therapeutic approach for treating liver damage caused by chemotherapy.
کلیدواژه‌های انگلیسی مقاله Apoptosis, Endometrial mesenchymal, stem cells, Liver regeneration, Hepatotoxicity, Menstrual blood
نویسندگان مقاله | parastoo noory
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.


| Hamed Hajmoradi
Department of Internal Medicine, School of Medicine, AJA University of Medical Sciences, Tehran, Iran.


| Mehdi Abbasi
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Naghmeh Bahrami
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Jafar Ai
Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-2510-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Cell, Stem Cell and Cancer
نوع مقاله منتشر شده Experimental research article
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