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Physiology and Pharmacology، جلد ۲۹، شماره ۴، صفحات ۴۶۴-۴۷۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Exploring the antidepressant-like effects of atorvastatin in ovariectomized mice: involvement of the nitric oxide pathway
چکیده انگلیسی مقاله Introduction: Atorvastatin, a lipid-soluble statin, is commonly used in managing high cholesterol levels and has been demonstrated to possess pleiotropic effects, such as antidepressant and neuroprotective properties. Women are more likely to suffer from depression because hormone levels change during ovariectomy and menopause. However, the role of statins in the treatment of ovariectomy-induced depressive behavior has not been adequately studied. We explored atorvastatin’s potential antidepressant effects as well as the potential function of the nitric oxide pathway in ovariectomized (OVX) mice. Methods: Female mice underwent ovary removal, followed by administration of varying doses of atorvastatin alone or in conjunction with either a non-specific NO synthase inhibitor (L-NAME) or an NO precursor (L-arginine). Behavioral alterations were assessed using the Tail Suspension Test (TST), Forced Swim Test (FST), and Open Field Test (OFT), while hippocampal nitrite levels were also measured. Results: One week post-procedure, OVX mice displayed a notably longer period of immobility in comparison to the sham group. OVX animals treated with atorvastatin (0.1 and 1 mg/kg) demonstrated antidepressant properties; additionally, OVX mice that received a sub effective dose of atorvastatin plus a sub-effective dose of L–NAME demonstrated pronounced antidepressant-like effects (P<0.05). L-arginine counteracted the antidepressant-like effects of a high dose of atorvastatin in OVX mice but did not affect their levels of locomotor activity in the OFT. Furthermore, atorvastatin administration prevented the increased hippocampal nitrite concentrations caused by ovariectomy (P<0.05). Conclusion: The research revealed that atorvastatin exhibits significant antidepressant properties in OVX mice, potentially by suppressing the nitric oxide pathway.
کلیدواژه‌های انگلیسی مقاله Ovariectomy, Depression, Atorvastatin, Nitric Oxide, Mice
نویسندگان مقاله | samane jahanabadi
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Pegah Safshekan
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Ali Moradi
Department of Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
نشانی اینترنتی http://ppj.phypha.ir/browse.php?a_code=A-10-2426-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Neurophysiology/Pharmacology
نوع مقاله منتشر شده Experimental research article
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