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Iranian Journal of Nuclear Medicine، جلد ۳۴، شماره ۱، صفحات ۶۳-۶۶
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عنوان انگلیسی [99mTc]Tc-MDP uptake in the prostate gland confirmed by SPECT/CT
چکیده انگلیسی مقاله Prostate cancer remains a leading cause of cancer-related mortality among men worldwide. Technetium-99m methylene diphosphonate ([99mTc]Tc-MDP) bone scintigraphy is commonly employed to detect skeletal metastases due to its high sensitivity in identifying osteoblastic activity. However, [99mTc]Tc-MDP uptake in soft tissues, particularly in the prostate gland, is exceedingly rare. Here, we present a case of a 70-year-old male with acinar prostate adenocarcinoma (Gleason score 7/10) and persistent lower back pain. [99mTc]Tc-MDP scintigraphy demonstrated abnormal radiotracer uptake in the prostate gland without any evidence of bone metastases. Further evaluation through performing SPECT/CT confirmed the radiotracer uptake in the prostate gland without evidence of calcification. This rare finding emphasizes recognizing atypical imaging patterns and accurately interpreting them, which are important for clinical decision-making. We evaluate the patient regarding the potential mechanisms for such uptake, including dystrophic calcification and localized osteoblastic activity, and discuss the diagnostic implications and future research directions in prostate cancer imaging.
کلیدواژه‌های انگلیسی مقاله prostate cancer,[99mTc]Tc-MDP,Bone scintigraphy,Soft tissue uptake,Pitfall
نویسندگان مقاله Farshid Gheisari |
Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Masoumeh Dehghani |
Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Babak Yazdani |
Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Saeed Amiri |
Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Kamali |
Department of Nuclear Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی http://irjnm.tums.ac.ir/article_40580_9c4000eaa1423717fe1963e39a9d70cb.pdf
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