| چکیده انگلیسی مقاله |
Background: Inflammatory indices have been linked to mood disorders. We aimed to examine whether these inflammatory indices are associated with the severity of depression and anxiety as measured by Beck scores. Methods: This cross-sectional analysis included 9,704 participants aged 35–65 years from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. Depression and anxiety were assessed using the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Inflammatory indices were calculated based on hematological and biochemical parameters. Multinomial logistic regression was applied to evaluate the associations between inflammatory markers and mood disorder severity. Results: In cases of severe depression, the neutrophil-to-lymphocyte ratio (NLR), white blood cell (WBC) count, and serum high-sensitivity C-reactive protein (hs-CRP) levels were significantly higher (OR = 1.29, 1.08, and 1.01, respectively; P < 0.05) than in individuals with minimal depression. Serum hs-CRP levels were also significantly higher (OR = 0.98; 95% CI: 0.95–0.99) in participants with moderate anxiety compared with those with minimal anxiety. Conclusion: Higher levels of depression were associated with increased inflammatory hematological indices, and that the severity of depression was related to elevated levels of NLR, WBC, and hs-CRP. |
| نویسندگان مقاله |
| Mina Nosrati
1. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran 2. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Hossein Hatamzadeh
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Amin Mansoori
1. Department of Applied Mathematics, Ferdowsi University of Mashhad, Iran 2. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 3. Mathematical Biology Research Laboratory (MBRL), Faculty of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran
| Mahsa Tousi
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Shakiba Najjar Khalilabad
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Fatemeh Rojoee
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
| Fatemeh Mohammadyari
School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
| Gordon A Ferns
Department of Medical Education, Brighton and Sussex Medical School, Brighton, United Kingdom
| Habibollah Esmaily
1. Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2. Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
| Majid Ghayour-Mobarhan
1. International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran 2. Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
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