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Iranian Journal of Public Health، جلد ۵۴، شماره ۱۲، صفحات ۲۷۵۴-۲۷۶۳
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عنوان انگلیسی Specific Genes and microRNAs as Novel Diagnostic Biomarkers for the Potential Progression of Pulmonary Arterial Hypertension
چکیده انگلیسی مقاله Background: Pulmonary arterial hypertension (PAH) is characterized by high blood pressure in the lungs due to obstruction of small pulmonary arteries. Its exact cause is unknown. We aimed to identify specific genes, signaling pathways, and microRNAs (miRNAs) as novel diagnostic biomarkers for PAH progression. Methods: We analyzed differentially expressed genes (DEGs) from PAH and control samples in the GSE144932 and GSE131793 datasets using GEO2R. We performed GO enrichment and KEGG pathway analyses. miRNAs targeting common DEGs were identified using miRDB and TargetScan. Results: MYLK and CLU were upregulated in both datasets, implicating calcium signaling and coagulation pathways, respectively. In silico analysis showed that miR-9-5p, miR-3179, and miR-580-3p potentially target MYLK; miR-369-3p potentially targets CLU; and miR-499a-5p potentially targets both. Conclusion: This study identifies MYLK and CLU, and their associated miRNAs (miR-9-5p, miR-3179, miR-580-3p, miR-499a-5p, and miR-369-3p), as potential noninvasive diagnostic biomarkers for PAH, requiring experimental validation. 
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نویسندگان مقاله | Akram Gholipour
Cardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran


| Molood Farsi
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran


| Faezeh Sari
Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran


| Zahra Khajali
1. Cardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran 2. Congenital Heart Diseases Research Center, Rajaie Cardiovascular Institute, Tehran, Iran


| Majid Maleki
Cardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran


| Mahshid Malakootian
1. Cardiogenetic Research Center, Rajaie Cardiovascular Institute, Tehran, Iran 2. Vascular Disease and Thrombosis Research Center, Rajaie Cardiovascular Institute, Tehran, Iran
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/38971
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