| چکیده انگلیسی مقاله |
Background: Human T-lymphotropic virus type 1 (HTLV-1) is considered a health issue in Iran. However, its genetic diversity and molecular epidemiologic phylogeny remain poorly characterized. Methods: The Tax gene of 9 asymptomatic individuals across Alborz, Gilan, and Ardabil provinces of Iran was sequenced and analyzed phylogenetically using MEGA-X. Results: All strains clustered within the Cosmopolitan subtype a, showing high genetic similarity to Japanese and Chinese references. Positive selection (dN/dS > 1) was observed in all samples. Strikingly, the Alborz ISO32 strain exhibited 10 unique nonsynonymous mutations, suggesting regional evolutionary divergence. Conclusion: This study, as the first multi-provincial study in Iran, reveals the essential requirement for systematic tracking of HTLV-1 genetic diversity and designing prevention programs tailored to each region. |
| نویسندگان مقاله |
| Bezhan Noori
1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Infectious Diseases and Tuberculosis, Kabul Medical University of Sciences, Kabul, Afghanistan
| Atefeh Bahavar
Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
| Zohreh Sharifi
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
| Parnaz Kafialqora
Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
| Zahra Navi
Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran
| Abbas Rahimi Foroushani
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
| Mohammadreza Shafiei
Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran
| Seyed Mohammad Jazayeri
1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
| Sayed-Hamidreza Mozhgani
1. Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran 2. Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
| Mehdi Norouzi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
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