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مجله پزشکی ارومیه، جلد ۳۶، شماره ۳، صفحات ۱۹۵-۲۰۲
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عنوان انگلیسی Chemical Profile, Antioxidant Potential, and Antibacterial Activity of Heracleum persicum Essential Oil against Staphylococcus aureus and Escherichia coli
چکیده انگلیسی مقاله Abstract
Background and Aim: The medicinal plant Heracleum persicum has attracted attention due to its bioactive compounds and antimicrobial properties. This study aimed to identify the constituents of essential oil from dried H. persicum fruits and evaluate its antibacterial and antioxidant activities.
Materials and Methods: Essential oil was extracted from dried fruits using a Clevenger-type distillation apparatus. The components were identified by gas chromatography–mass spectrometry. Total phenolic and flavonoid contents were determined. Antibacterial activity against Staphylococcus aureus and Escherichia coli was assessed using the disk diffusion method and by determining the minimum inhibitory concentration. Antioxidant activity was measured using the DPPH radical scavenging assay.
Results: Thirty-one compounds were identified, with n-hexyl butyrate (49.98%) and octyl acetate (15.39%) being the most abundant. The essential oil contained high levels of phenolics (108.25 ± 0.1 mg/g) and flavonoids (21.29 ± 0.1 mg/g). Its antioxidant activity was lower than BHT (IC50 = 1443.92 µg/mL). Significant antibacterial effects were observed against Staphylococcus aureus (MIC = 0.2 mg/mL) and, to a lesser extent, Escherichia coli (MIC = 0.5 mg/mL), whereas activity against other tested bacteria was weaker (MIC > 16 mg/mL).
Conclusion: The essential oil of H. persicum fruits contains bioactive compounds and exhibits notable antibacterial activity, particularly against Staphylococcus aureus. Its antioxidant activity was lower than the synthetic antioxidant BHT, and further studies are required to assess safety and efficacy in in vivo conditions.
کلیدواژه‌های انگلیسی مقاله Antibacterial agent, Escherichia coli, Essential oil, Heracleum persicum, Staphylococcus aureus
نویسندگان مقاله | Amirmohammad Hajati
School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran


| Edris Mahdavi Fikjvar
Medical Biotechnology Research Centre, School of Paramedicine, Guilan University of Medical Sciences, Guilan, Iran


| Maedeh Mohammadi Jonaghani
Department of Cell and Molecular Biology, Faculty of Science and Advanced Biological Technologies, Tehran East Branch, Islamic Azad University, Tehran, Iran


| Parisa Satvat
Department of Cell and Molecular Biology, Faculty of Science and Advanced Biological Technologies, Tehran East Branch, Islamic Azad University, Tehran, Iran


| Nooshin Amini
Member of the Scientific Committee and Management, Global Network for Research, Education, and Events (GREEN), Tehran Representative Office, Iran
نشانی اینترنتی http://umj.umsu.ac.ir/browse.php?a_code=A-10-5872-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماکولوژی
نوع مقاله منتشر شده پژوهشی(توصیفی- تحلیلی)
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