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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۲۴، شماره ۹۶، صفحات ۳۷-۵۲
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation of the antidepressant-like activity of essential oil from <i>Citrus medica</I> fruits (L.) in mice: Involvement of CREB and BDNF
چکیده انگلیسی مقاله
Background: Major depressive disorder affects more than 300 million people worldwide. Citrus medica L. essential oil (CMEO), rich in terpenes such as limonene, has shown antidepressant-like effects in preclinical models, potentially through hippocampal BDNF/CREB signaling, and may offer a safer natural alternative to conventional antidepressants. Objective: This study aimed to investigate the antidepressant-like effects of CMEO on depression-like behaviors induced by lipopolysaccharide (LPS) in mice and to elucidate potential underlying mechanisms involving hippocampal BDNF/p-CREB signaling and brain nitric oxide (NO) levels. Methods: CMEO composition w:as char:acterized by gas chromatography–mass spectrometry (GC-MS). Depression-like behavior was induced by intraperitoneal LPS injection (1 mg/kg). Mice were randomly assigned to four groups: Control, LPS, CMEO 50 mg/kg + LPS, and CMEO 100 mg/kg + LPS. Behavioral assessments included the Forced Swimming Test (FST), Tail Suspension Test (TST), and Open Field Test (OFT). Biochemical analyses measured hippocampal phosphorylated CREB (p-CREB) and brain-derived neurotrophic factor (BDNF), as well as brain NO levels. Results: GC-MS identified ten CMEO constituents, with limonene as the dominant compound (93.96%). CMEO at 50 and 100 mg/kg significantly reduced immobility time in the FST and TST versus the LPS group, indicating attenuated depressive-like behavior. CMEO also restored hippocampal BDNF and p-CREB levels and significantly reduced LPS-elevated NO. Conclusion: CMEO alleviates depression-like behaviors in an LPS-induced mouse model, potentially via upregulation of hippocampal BDNF and p-CREB and reduction of NO. The high limonene content may contribute to these effects, supporting CMEO as a promising natural candidate for managing depressive disorders.
کلیدواژه‌های انگلیسی مقاله Citrus medica, Lipopolysaccharide, Depression, cAMP response element-binding protein, Brain-Derived Neurotrophic Factor, Antidepressant-like effect
نویسندگان مقاله | Neda Kari-Khameneh
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Samira Shirooie
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Mitra Tarlan
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran


| Mohammad Hosein Farzaei
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-688-11&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده فارماکوگنوزی و فارماسیوتیکس
نوع مقاله منتشر شده پژوهشی
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