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International Journal of Radiation Research، جلد ۲۴، شماره ۱، صفحات ۳۱-۳۶
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عنوان انگلیسی Clinical effect and safety of programmed cell death protein 1/programmed death ligand-1 blockers in postoperative chemotherapy for advanced colorectal cancer
چکیده انگلیسی مقاله
Background: This research was planned to disclose the clinical effect along with safety of programmed cell death protein 1/programmed death ligand-1 (PD-1/PD-L1) blockers in postoperative chemotherapy for advanced colorectal cancer. Material and Methods: From June 2019 to June 2021, 23 advanced colorectal cancer patients received apatinib treatment and 28 advanced colorectal cancer patients received PD-1 inhibitors in our hospital were included. The safety and clinical efficacy of 2 therapeutic regimens were compared. Results: Relative to apatinib group, the proportion of stable disease in patients accepting PD-1 blockers presented higher (P=0.010), the median progression-free survival (PFS) of patients accepting PD-1 blockers was longer (P=0.0209), the median PFS of patients with no liver metastasis who accepted PD-1 blockers presented longer (P<0.0001), the median PFS of Kirsten rat sarcoma viral oncogene homolog (KRAS) wild-type patients who received anti-PD-1 therapy presented longer (P=0.0288), and the median PFS of patients with left colon as primary site who received anti-PD-1 therapy presented longer (P=0.0105). Relative to the apatinib group, the incidence of adverse events in patients accepting PD-1 blockers was generally lower, but with no difference (P>0.05). Conclusion: PD-1/PD-L1 blockers possess certain clinical efficacy and tolerability in treating advanced colorectal cancer.
کلیدواژه‌های انگلیسی مقاله Colorectal cancer, PD-1, PD-L1, apatinib, efficacy, safety.
نویسندگان مقاله | G.L. Liu
Department of Geriatrics and Respiratory Medicine, The Afffliated Tai&apos;an City Central Hospital of Qingdao University, Tai&apos;an 271000, Shandong, China


| W.R. Yang
Department of Clinical Nutrition, The Afffliated Tai&apos;an City Central Hospital of Qingdao University, Tai&apos;an 271000, Shandong, China


| M. Cheng
Department of Gastrointestinal Surgery, The Afffliated Tai&apos;an City Central Hospital of Qingdao University, Tai&apos;an 271000, Shandong, China


| C.L. Wang
Department of Gastrointestinal Surgery, The Afffliated Tai&apos;an City Central Hospital of Qingdao University, Tai&apos;an 271000, Shandong, China


| M. Liu
Department of Gastrointestinal Surgery, The Afffliated Tai&apos;an City Central Hospital of Qingdao University, Tai&apos;an 271000, Shandong, China


| X. Zheng
Department of Gastrointestinal Surgery, The Afffliated Tai&apos;an City Central Hospital of Qingdao University, Tai&apos;an 271000, Shandong, China
نشانی اینترنتی http://ijrr.com/browse.php?a_code=A-10-1-1451&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Radiation Biology
نوع مقاله منتشر شده تحقیق بدیع
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