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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰، شماره ۱، صفحات ۴۶-۵۸
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عنوان انگلیسی The Role of miRNA-21 in the Metastasis of Hepatocellular Carcinoma as a Therapeutic Target
چکیده انگلیسی مقاله Hepatocellular carcinoma (HCC) is a crucial health concern worldwide, representing a leading cause of cancer-related mortality and the most common form of primary liver cancer. The aggressive nature of HCC is mainly due to its high intention for invasion and metastasis, processes that are regulated by a complex network of genetic and molecular pathways. Among the critical regulators of these processes is microRNA-21 (miR-21), a small non-coding RNA that has been implicated in various oncogenic activities. This review provides a comprehensive analysis of the role of miR-21 in promoting HCC metastasis progression, with a particular focus on its interaction with key signaling pathways, including the PTEN/PI3K/AKT, PDCD4/AP-1, RECK/MMP, and TIMP-3 axes. By targeting tumor suppressors, miR-21 facilitates epithelial-to-mesenchymal transition (EMT), invasion, and metastasis of HCC cells. Understanding the molecular mechanisms regulated by miR-21 not only sheds light on the pathogenesis of HCC but also highlights possible therapeutic targets for combating this aggressive cancer.
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نویسندگان مقاله | Mahdi Alaee
Shahid Rajaee Hospital, Qazvin University of Medical Sciences, Qazvin, Iran


| Meysam Moulaee
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Kimia Taebi
1) Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran 2)USERN Office, Qazvin University of Medical Sciences, Qazvin, Iran


| Ahoura Haghi
Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Italy


| Maryam Hormozi
Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran


| Mehdi Azad
Department of Medical Laboratory Sciences, Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2388
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