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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۲۰، شماره ۱، صفحات ۹۷-۱۰۲
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عنوان انگلیسی Mesenchymal Stem Cell Therapy for Oral Lichen Planus: A Paradigm Shift from Palliation to Regeneration?
چکیده انگلیسی مقاله Oral lichen planus (OLP) is a chronic, T-cell-mediated inflammatory disease of the oral mucosa, notable for its symptomatic burden and potential for malignant transformation. While corticosteroids and immunosuppressants remain the standard of care, their transient efficacy and adverse effect profile underscore a significant unmet clinical need. Mesenchymal stem cells (MSCs), with their multifaceted immunomodulatory and regenerative capabilities, are emerging as a compelling therapeutic alternative. This editorial synthesizes current evidence, positing that MSCs can fundamentally disrupt the immunopathogenic cycle of OLP. We explore the mechanisms by which MSCs re-establish immune tolerance and promote tissue repair, and we critically assess the translational pathway from preclinical models to clinical application. Despite promising results, the journey to clinical adoption necessitates overcoming hurdles in standardization, delivery, and safety profiling. We argue that MSC-based therapy represents not merely an incremental improvement, but a potential paradigm shift towards a curative strategy for this recalcitrant disease.
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نویسندگان مقاله | Shahabodin Babaeifard
Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran


| Mohaddese Marzban
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Ghazaleh Kheiri
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Leyla Sharifi Aliabadi
Cell Therapy and Hematopoietic Stem Cell Transplantation Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran


| Ghazal Razani
Hematologic Malignancies Research Center, Research Institute for Oncology, Hematology and Cell Therapy, Tehran University of Medical Sciences, Tehran, Iran.


| Maryam Barkhordar


نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/2615
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