| چکیده انگلیسی مقاله |
Background and Objectives: Numerous cases of mucormycosis appeared among COVID-19 patients, predominantly in Asian countries. This study aimed to investigate the clinical profile, in-hospital outcome, and one-year prognosis of COVID-19-associated mucormycosis (CAM). Materials and Methods: All patients who developed CAM in Shiraz, South Iran, between July and October 2021 were included in this study. We collected data on presentations, comorbidities, risk factors, and outcomes. Results: Sixty-two patients with CAM were analyzed; the mean age was 59.3 years, and 58.1% were male. Diabetes mellitus was present in 80.6% (11.2% uncontrolled), hypertension in 54.8%, and chronic kidney disease in 11.3%. All patients had sinonasal involvement; ophthalmic, cutaneous, cerebral, gastrointestinal, pulmonary, and renal involvement occurred in 41.9%, 8.1%, 6.4%, 6.4%, 1.6%, and 1.6%, respectively. In-hospital and one-year mortality were 40.3% and 48.3%. Concurrent CAM and COVID-19, hypertension, older age, and radiologically severe COVID-19 lung involvement were associated with higher mortality. In multivariable analysis, age ≥60 years predicted in-hospital (OR: 5.47; 95% CI: 1.53-19.56) and one-year mortality (OR: 7.65; 95% CI: 1.90-30.84). Long-term mortality was also associated with ≥3 risk factors (OR: 4.12; 95% CI: 1.09-15.52) and lung severity index >30 (OR: 9.35; 95% CI: 1.01-86.63). Conclusion: These findings emphasize the critical role of age in immune responses to opportunistic infections and highlight the impact of multiple comorbidities and severe lung damage on long-term prognosis in CAM. |
| نویسندگان مقاله |
| Pariya Kouhi
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Seyed Alireza Mirhosseini
Department of MD-MPH, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Maryam Ranjbar
Department of MD-MPH, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Mohammadreza Akbari
Department of Internal Medicine, Shiraz Nephro-Urology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Zeinab Mehrabi
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Rojan Javaheri
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Mahsa Moosavi
Department of Education, Clinical Education Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Mohammad Alishahi
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Kamran Rasekh
Department of Infectious Disease, Ali Asghar Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Nazanin Fathi
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
| Yasaman Mansoori
Department of Research, Health Policy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
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