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Journal of Kerman University of Medical Sciences، جلد ۳۳، شماره ۱، صفحات ۱-۷
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عنوان انگلیسی Assessment of Serum Interleukin-38 Levels in Iranian Patients with Benign and Malignant Salivary Gland Cancers: A Case-Control Study
چکیده انگلیسی مقاله Background: Similar to other cancers, the development of salivary gland cancers (SGCs) is influenced by the tumor microenvironment and controlled by the host's immune system. Interleukin-38 (IL-38) is highly expressed in inflammatory conditions to prevent excessive inflammatory responses and tissue injury; however, its role in SGCs remains unclear. This study aimed to evaluate IL-38 serum levels in Iranian patients with benign and malignant SGCs and in healthy individuals to explore its potential as a diagnostic biomarker for SGCs.
Methods: In this retrospective cross-sectional study, IL-38 levels were measured in serum samples from 120 patients with SGCs (64 benign and 56 malignant cases) and 60 age- and sex-matched healthy control participants using a sandwich enzyme-linked immunosorbent assay (ELISA) kit.
Results: There was a significant difference in IL-38 serum levels between patients and the control group (49.1 ± 6.2 ng/L vs. 38.6 ± 6.8 ng/L, p < 0.0001), but not between benign and malignant cases (48.2 ± 7.1 ng/L vs. 50.2 ± 4.8 ng/L, p = 0.085). A significant negative correlation was observed between SGC size and IL-38 serum levels (R = −0.195, p = 0.042). However, IL-38 was not associated with other clinicopathologic factors, including gender, age, tumor type, lesion location, and tumor stage (p > 0.05).
Conclusion: This study, for the first time, supports the clinical value of IL-38 serum levels as a valuable biomarker for diagnosing patients with SGCs. Focusing on IL-38 production or its release mechanism could offer therapeutic benefits for these patients. However, further research with a larger sample is required.
کلیدواژه‌های انگلیسی مقاله Salivary Gland Neoplasms,Interleukin-38,Prognosis
نویسندگان مقاله Ali Tadayon |
Department of Surgery, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Javad Moayedi |
Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Javad Fattahi |
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Behnaz Nazari |
Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

Maryam Mardani |
Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

نشانی اینترنتی https://jkmu.kmu.ac.ir/article_92996_48793fe898037d07eef6c8e79269a496.pdf
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