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Iranian Journal of Blood and Cancer، جلد ۱۷، شماره ۴، صفحات ۶۹-۸۱
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عنوان انگلیسی A Meta-Analysis on the Prognostic and Predictive Role of Stem-like CD8+ T Cells in Cancer Immunotherapy: Correlating Clinical Outcomes
چکیده انگلیسی مقاله
Background: Stem-like CD8+ T cells, marked by TCF1 and PD-1, possess self-renewal and effector differentiation abilities, crucial for cancer immunotherapy. Despite tumor microenvironment constraints, their abundance often correlates with favourable outcomes.
Aim: To assess the prognostic and predictive relevance of stem-like CD8+ T cells in patients receiving immunotherapy for cancer.
Methodology: 721 publications from PubMed, Embase, Scopus, and Web of Science (2015–2025) were evaluated in accordance with PRISMA 2020 guidelines. 8 studies were included in the meta-analysis. Two independent reviewers conducted data extraction. Pooled hazard ratios (HRs) and confidence intervals (CIs) were calculated using RevMan software, and the I2 statistic was employed to measure heterogeneity. The ROBINS-I instruments and the Newcastle-Ottawa Scale were used to assess the quality of the study.
Results: 8 of the 13 included papers qualified for meta-analysis. Follow-up periods varied from six months to five years, and sample sizes ranged from 12 to 94 patients. Multiplex immunofluorescence, scRNA-seq, or flow cytometry were used to quantify stem-like CD8+ T cells. Hazard ratios (HRs) in the woodland plot ranged from 1.18 to 28.50. High HRs of 4.31 (95% CI: 2.68–6.92) and 28.50 (95% CI: 3.30–246.15) were observed in two investigations, suggesting a significant adverse prognostic effect. With considerable heterogeneity (I2 = 89%, Chi2 = 61.38, P < 0.00001), the pooled HR was 1.34 (95% CI: 1.22–1.47).
Conclusion: In cancer immunotherapy, stem-like CD8+ T cells serve as both therapeutic targets and significant prognostic indicators. Standardized methods for evaluation and strategies to lessen immunosuppressive effects in the tumor microenvironment are necessary for clinical use.
کلیدواژه‌های انگلیسی مقاله Cancer Immunotherapy, CD8 Positive T Lymphocytes, Immunologic Surveillance, Stem Cells, T Cell Exhaustion
نویسندگان مقاله | Sonika Sharma
Department of Anatomy, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.


| Prithpal Singh Matreja
Department of Pharmacology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.


| Sudhir Singh
Department of Microbiology, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.


| Pothu Usha Kiran
Department of Biochemistry, Teerthanker Mahaveer Medical College & Research Centre, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India.
نشانی اینترنتی http://ijbc.ir/browse.php?a_code=A-10-2116-1&slc_lang=en&sid=1
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زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Adults Hematology & Oncology
نوع مقاله منتشر شده متا آنالیز
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