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Iranian Journal of Kidney Diseases، جلد ۲۰، شماره ۰۱، صفحات ۴۶-۵۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Protective Effect of Garlic on Diazinon Induced Kidney Toxicity in Rat: A Biochemical and Histopathological Evaluation
چکیده انگلیسی مقاله Introduction. Diazinon (DZN) is a widely used pesticide applied in agriculture to eliminate pests, but it can cause adverse effects on various  organs.  This  study  investigated  the  nephrotoxic  changes and oxidative stress induced by diazinon, as well as the potential protective  role  of  garlic  in  ameliorating  kidney  toxicity  in  male Wistar rats.Methods. The animals were treated with diazinon (DZN; 70 mg/ kg/day, orally) with or without garlic extract (500 mg/kg, orally) for four consecutive weeks. Biomarkers including malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), superoxide dismutase  (SOD),  and  total  thiol  molecules  were  measured  to evaluate oxidative stress. In addition, kidney histopathology was examined using the hematoxylin and eosin (H&E) staining.Results and conclusion. As expected, DZN significantly increased MDA  levels  while  decreased  the  levels  of  CAT,  SOD,  TAC,  and total  thiol  molecules  in  kidney  tissue.  Co-treatment  with  garlic reversed the oxidative stress status. Moreover, garlic ameliorated the kidney histopathological injuries induced by DZN. Our findings suggest that garlic can be considered a safe and effective agent for mitigating DZN-induced nephrotoxicity.
کلیدواژه‌های انگلیسی مقاله Diazinon,Nephrotoxicity,Garlic,Kidney,Oxidative stress
نویسندگان مقاله | Saeed Afzali
Department of Forensic Medicine, School of Medicine Behavioral Disorders and Substance Abuse Research Center Institute of Mental Health and Addiction Sina (Farshchian) Educational and Medical Center Hamadan University of Medical Sciences, Hamadan, Iran.


| Behnaz Alafchi
Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.


| Elham Shiri
Assistant Professor of Anatomical Sciences Department of Anatomical Sciences, School of Medicine Hamadan University of Medical Sciences; Hamadan, Iran.


| Fereshteh Mehri
Behavioral Disorders and Substance Abuse Research Center, Institute of Neuroscience and Mental Health, Hamadan University of Medical Sciences, Hamadan, Iran, Hamadan, Iran.
نشانی اینترنتی https://ijkd.org/index.php/ijkd/article/view/8158
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.61882/ijkd.20.01.8158
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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