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Iranian Journal of Kidney Diseases، جلد ۱۹، شماره ۰۵، صفحات ۲۷۲-۲۷۸
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Examining the Association between Oxidative Stress Markers and the Severity of Symptoms in Individuals with COVID-19 and Healthy Individuals
چکیده انگلیسی مقاله Introduction. The association between inflammation and oxidative stress  in  COVID-19  patients  is  well  documented.  The  primary objective of the present study was to evaluate the levels of oxidative stress  markers  in  COVID-19  patients  compared  to  the  healthy individuals. Methods. In this case-control study, a comprehensive evaluation was conducted on 45 individuals, comprising 30 patients diagnosed with  COVID-19  and  15  in  a  healthy  control.  COVID-19  patients were divided into two groups: mild and severe, based on clinical severity. In addition to standard laboratory tests like ESR, serum levels of oxidative stress markers were measured, including total protein, total antioxidant capacity, total oxidant status, carbonylated protein content, glutathione reductase enzyme, and catalase activity.Results. ESR levels were significantly elevated in the severe group compared to the mild group. However, no significant differences were  observed  in  the  levels  of  oxidative  stress  markers  between mild and severe COVID-19 patients. Compared to healthy controls, COVID-19 patients exhibited a significant decrease in total protein levels (P < .0001), and significant increases were observed in serum total antioxidant capacity (TAC) (P < .0001) and total oxidant status(TOS) (P = .002).Conclusion. Oxidative  stress  markers  exhibit  a  substantial  rise in  patients  with  COVID-19, suggesting  a  potential  role  in  the progression  of  the  disease.  Implementing  strategies  to prevent oxidative  stress  may  offer  clinical  advantageous  in  managing COVID-19 patients.
کلیدواژه‌های انگلیسی مقاله Oxidative stress,COVID-19,Total antioxidant capacity,Total oxidant status,Catalase activity
نویسندگان مقاله | Fatemeh Pourrezagholi
Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Masoumeh Ebrahimi
Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Yadollah Shakiba
Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.


| Hossein Amini
Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran


| Mohammad Rahmanian
Department of Nephrology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China. AND Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Tayebe Zomorrodi Jangaee
MSc student in Environmental Health, Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Iran.


| Zahra Golkar
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.


| Shideh Anvari
Department of Cardiology, Labbafinejad hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


| Nooshin Dalili
Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
نشانی اینترنتی https://ijkd.org/index.php/ijkd/article/view/8785
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.61186/
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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